Einfluss der Ca2+/Calmodulin-abhängigen Proteinkinase II delta auf den L-Typ Ca2+-Strom -Untersuchungen anhand eines genetischen Knock-outs im Mausmodell
Influence of ca2+/calmodulin-dependent kinase II delta on l-type ca2+-current - investigations using a knockout model in mice
von Victor Neuhaus
Datum der mündl. Prüfung:2016-12-20
Erschienen:2016-12-20
Betreuer:Prof. Dr. Lars Maier
Gutachter:Prof. Dr. Blanche Schwappach-Pignataro
Gutachter:Prof. Dr. Martin Oppermann
Dateien
Name:Diss19122016.pdf
Size:778.Kb
Format:PDF
Zusammenfassung
Englisch
Ca2+/calmodulin-dependent kinase II delta plays an important role in heart failure as activity and expression of the kinase are higher in myocytes of failing hearts. In this dissertation transverse aortic constriction led to cardiac hypertrophy and increase of l-type ca2+-current in murine myocytes. Inhibition of ca2+/calmodulin-dependent kinase II delta using autocamtide-2-related inhibitory peptide and genetic knockout normalized l-type ca2+-current.
Keywords: ca2+/calmodulin-dependent kinase II delta