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dc.contributor.advisor Meller, Johannes Prof. Dr.
dc.contributor.author Braune, Isabell
dc.date.accessioned 2017-01-18T09:33:29Z
dc.date.available 2017-02-02T23:50:31Z
dc.date.issued 2017-01-18
dc.identifier.uri http://hdl.handle.net/11858/00-1735-0000-002B-7D19-5
dc.language.iso deu de
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc 610 de
dc.title Klinischer Stellenwert der Time of Flight FDG-PET/CT bei entzündungsspezifischen Fragestellungen de
dc.type doctoralThesis de
dc.title.translated Clinical value of Time of Flight FDG-PET/CT in detecting of infection and inflammation de
dc.contributor.referee Meller, Johannes Prof. Dr.
dc.date.examination 2017-01-26
dc.description.abstracteng The purpose of this study was to assess the value of Time of Flight FDG-PET/CT in detecting of infection and inflammation. This study is a retrospective analysis of the data from 115 patients (m = 71, f = 44) with a suspected diagnosis of infection or inflammation examined with 18F-FDG-PET/CT in the nuclear medicine department of the University Medical Centre Göttingen (UMG) during 2009 to 2012. The results of 18F-FDG-PET/CT scans were compared with the results of histological, bacteriological, serological, radiological and endoscopic techniques and the final clinical diagnosis. Follow-up for 3 months was mandatory for inclusion into the retrospective analysis. All patients were examined with FDG-PET/CT (Gemini TF, Philips, Germany). 72 patients received additional contrast-enhanced CT. The sensitivity in the total patient group was 83% and the specificity 89 %, respectively. The positive predictive value was 94 % and the negative predictive value 72 %. In 52 patients (45 %) the FDG-PET/CT was helpful in establishing the final diagnosis. Sensitivity and specificity in patients with prolonged fever of unknown origin (n = 32) were 70 % and 100 %. The positive predictive value was 100 % and the negative predictive value 56 %. In 12 patients (38 %) the FDG-PET/CT was helpful in establishing the final diagnosis. The sensitivity and specificity in patients with inflammation of unknown origin (n = 44) were 88 % and 70 %. The positive predictive value was 91 % and the negative predictive value 64 %. In 23 patients (52 %) the FDG-PET/CT was helpful in establishing the final diagnosis. In the group of patients with large vessel vasculitis (n = 15) was a sensitivity of 67 % and a specificity of 100 % found. The positive predictive value was 100 % and the negative predictive value 82 %. In 6 patients (40 %) the FDG-PET/CT was helpful in establishing the final diagnosis. In the group of patients with musculoskeletal infections (n = 24) the sensitivity was 100 % and the specificity 89 %. The positive predictive value was 94 % and the negative predictive value 100 %. In 11 patients (46 %) the FDG-PET/CT was helpful in establishing the final diagnosis. Conclusions: FDG-PET/CT is a valuable imaging technique in patients with fever and inflammation of unknown origin and in the diagnosis of vasculitis and musculoskeletal infections. In comparison to the published FDG-PET data the number of conclusive findings was tendentially higher. de
dc.contributor.coReferee Blaschke, Sabine Prof. Dr.
dc.contributor.thirdReferee Ritter, Christian O. Prof. Dr.
dc.contributor.thirdReferee Meyer, Thomas Prof. Dr.
dc.subject.ger FDG de
dc.subject.ger PET de
dc.subject.ger CT de
dc.subject.ger Fieber unklarer Genese de
dc.subject.ger FUO de
dc.subject.ger Infektion de
dc.subject.ger Entzündung unklarer Genese de
dc.subject.ger IUO de
dc.subject.ger Vaskulitis de
dc.subject.ger Großgefäßvaskulitis de
dc.subject.ger Riesenzellarteriitis de
dc.subject.ger Takayasu-Arteriitis de
dc.subject.ger Osteomyelitis de
dc.subject.ger Protheseninfektion de
dc.subject.eng FDG de
dc.subject.eng PET de
dc.subject.eng CT de
dc.subject.eng fever of unknown origin de
dc.subject.eng FUO de
dc.subject.eng infection de
dc.subject.eng inflammation of unknown origin de
dc.subject.eng IUO de
dc.subject.eng vasculitis de
dc.subject.eng large vessel vasculitis de
dc.subject.eng giant cell arteritis de
dc.subject.eng Takayasu arteritis de
dc.subject.eng osteomyelitis de
dc.subject.eng infection of hip arthroplasty de
dc.subject.eng infection of knee arthroplasty de
dc.identifier.urn urn:nbn:de:gbv:7-11858/00-1735-0000-002B-7D19-5-6
dc.affiliation.institute Medizinische Fakultät de
dc.subject.gokfull Radiologie / Bildgebende Verfahren / Ultraschall / Nuklearmedizin / Strahlenschutz - Allgemein- und Gesamtdarstellungen (PPN619875585) de
dc.description.embargoed 2017-02-02
dc.identifier.ppn 877371288

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