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Klinischer Stellenwert der Time of Flight FDG-PET/CT bei entzündungsspezifischen Fragestellungen

dc.contributor.advisorMeller, Johannes Prof. Dr.
dc.contributor.authorBraune, Isabell
dc.date.accessioned2017-01-18T09:33:29Z
dc.date.available2017-02-02T23:50:31Z
dc.date.issued2017-01-18
dc.identifier.urihttp://hdl.handle.net/11858/00-1735-0000-002B-7D19-5
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-6089
dc.language.isodeude
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc610de
dc.titleKlinischer Stellenwert der Time of Flight FDG-PET/CT bei entzündungsspezifischen Fragestellungende
dc.typedoctoralThesisde
dc.title.translatedClinical value of Time of Flight FDG-PET/CT in detecting of infection and inflammationde
dc.contributor.refereeMeller, Johannes Prof. Dr.
dc.date.examination2017-01-26
dc.description.abstractengThe purpose of this study was to assess the value of Time of Flight FDG-PET/CT in detecting of infection and inflammation. This study is a retrospective analysis of the data from 115 patients (m = 71, f = 44) with a suspected diagnosis of infection or inflammation examined with 18F-FDG-PET/CT in the nuclear medicine department of the University Medical Centre Göttingen (UMG) during 2009 to 2012. The results of 18F-FDG-PET/CT scans were compared with the results of histological, bacteriological, serological, radiological and endoscopic techniques and the final clinical diagnosis. Follow-up for 3 months was mandatory for inclusion into the retrospective analysis. All patients were examined with FDG-PET/CT (Gemini TF, Philips, Germany). 72 patients received additional contrast-enhanced CT. The sensitivity in the total patient group was 83% and the specificity 89 %, respectively. The positive predictive value was 94 % and the negative predictive value 72 %. In 52 patients (45 %) the FDG-PET/CT was helpful in establishing the final diagnosis. Sensitivity and specificity in patients with prolonged fever of unknown origin (n = 32) were 70 % and 100 %. The positive predictive value was 100 % and the negative predictive value 56 %. In 12 patients (38 %) the FDG-PET/CT was helpful in establishing the final diagnosis. The sensitivity and specificity in patients with inflammation of unknown origin (n = 44) were 88 % and 70 %. The positive predictive value was 91 % and the negative predictive value 64 %. In 23 patients (52 %) the FDG-PET/CT was helpful in establishing the final diagnosis. In the group of patients with large vessel vasculitis (n = 15) was a sensitivity of 67 % and a specificity of 100 % found. The positive predictive value was 100 % and the negative predictive value 82 %. In 6 patients (40 %) the FDG-PET/CT was helpful in establishing the final diagnosis. In the group of patients with musculoskeletal infections (n = 24) the sensitivity was 100 % and the specificity 89 %. The positive predictive value was 94 % and the negative predictive value 100 %. In 11 patients (46 %) the FDG-PET/CT was helpful in establishing the final diagnosis. Conclusions: FDG-PET/CT is a valuable imaging technique in patients with fever and inflammation of unknown origin and in the diagnosis of vasculitis and musculoskeletal infections. In comparison to the published FDG-PET data the number of conclusive findings was tendentially higher.de
dc.contributor.coRefereeBlaschke, Sabine Prof. Dr.
dc.contributor.thirdRefereeRitter, Christian O. Prof. Dr.
dc.contributor.thirdRefereeMeyer, Thomas Prof. Dr.
dc.subject.gerFDGde
dc.subject.gerPETde
dc.subject.gerCTde
dc.subject.gerFieber unklarer Genesede
dc.subject.gerFUOde
dc.subject.gerInfektionde
dc.subject.gerEntzündung unklarer Genesede
dc.subject.gerIUOde
dc.subject.gerVaskulitisde
dc.subject.gerGroßgefäßvaskulitisde
dc.subject.gerRiesenzellarteriitisde
dc.subject.gerTakayasu-Arteriitisde
dc.subject.gerOsteomyelitisde
dc.subject.gerProtheseninfektionde
dc.subject.engFDGde
dc.subject.engPETde
dc.subject.engCTde
dc.subject.engfever of unknown originde
dc.subject.engFUOde
dc.subject.enginfectionde
dc.subject.enginflammation of unknown originde
dc.subject.engIUOde
dc.subject.engvasculitisde
dc.subject.englarge vessel vasculitisde
dc.subject.enggiant cell arteritisde
dc.subject.engTakayasu arteritisde
dc.subject.engosteomyelitisde
dc.subject.enginfection of hip arthroplastyde
dc.subject.enginfection of knee arthroplastyde
dc.identifier.urnurn:nbn:de:gbv:7-11858/00-1735-0000-002B-7D19-5-6
dc.affiliation.instituteMedizinische Fakultätde
dc.subject.gokfullRadiologie / Bildgebende Verfahren / Ultraschall / Nuklearmedizin / Strahlenschutz - Allgemein- und Gesamtdarstellungen (PPN619875585)de
dc.description.embargoed2017-02-02
dc.identifier.ppn877371288


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