dc.contributor.advisor | Meller, Johannes Prof. Dr. | |
dc.contributor.author | Braune, Isabell | |
dc.date.accessioned | 2017-01-18T09:33:29Z | |
dc.date.available | 2017-02-02T23:50:31Z | |
dc.date.issued | 2017-01-18 | |
dc.identifier.uri | http://hdl.handle.net/11858/00-1735-0000-002B-7D19-5 | |
dc.identifier.uri | http://dx.doi.org/10.53846/goediss-6089 | |
dc.language.iso | deu | de |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject.ddc | 610 | de |
dc.title | Klinischer Stellenwert der Time of Flight FDG-PET/CT bei entzündungsspezifischen Fragestellungen | de |
dc.type | doctoralThesis | de |
dc.title.translated | Clinical value of Time of Flight FDG-PET/CT in detecting of infection and inflammation | de |
dc.contributor.referee | Meller, Johannes Prof. Dr. | |
dc.date.examination | 2017-01-26 | |
dc.description.abstracteng | The purpose of this study was to assess the value of Time of Flight FDG-PET/CT in detecting of infection and inflammation.
This study is a retrospective analysis of the data from 115 patients (m = 71, f = 44) with a suspected diagnosis of infection or inflammation examined with 18F-FDG-PET/CT in the nuclear medicine department of the University Medical Centre Göttingen (UMG) during 2009 to 2012. The results of 18F-FDG-PET/CT scans were compared with the results of histological, bacteriological, serological, radiological and endoscopic techniques and the final clinical diagnosis. Follow-up for 3 months was mandatory for inclusion into the retrospective analysis. All patients were examined with FDG-PET/CT (Gemini TF, Philips, Germany). 72 patients received additional contrast-enhanced CT.
The sensitivity in the total patient group was 83% and the specificity 89 %, respectively. The positive predictive value was 94 % and the negative predictive value 72 %. In 52 patients (45 %) the FDG-PET/CT was helpful in establishing the final diagnosis.
Sensitivity and specificity in patients with prolonged fever of unknown origin (n = 32) were 70 % and 100 %. The positive predictive value was 100 % and the negative predictive value 56 %. In 12 patients (38 %) the FDG-PET/CT was helpful in establishing the final diagnosis.
The sensitivity and specificity in patients with inflammation of unknown origin (n = 44) were 88 % and 70 %. The positive predictive value was 91 % and the negative predictive value 64 %. In 23 patients (52 %) the FDG-PET/CT was helpful in establishing the final diagnosis.
In the group of patients with large vessel vasculitis (n = 15) was a sensitivity of 67 % and a specificity of 100 % found. The positive predictive value was 100 % and the negative predictive value 82 %. In 6 patients (40 %) the FDG-PET/CT was helpful in establishing the final diagnosis.
In the group of patients with musculoskeletal infections (n = 24) the sensitivity was 100 % and the specificity 89 %. The positive predictive value was 94 % and the negative predictive value 100 %. In 11 patients (46 %) the FDG-PET/CT was helpful in establishing the final diagnosis.
Conclusions: FDG-PET/CT is a valuable imaging technique in patients with fever and inflammation of unknown origin and in the diagnosis of vasculitis and musculoskeletal infections. In comparison to the published FDG-PET data the number of conclusive findings was tendentially higher. | de |
dc.contributor.coReferee | Blaschke, Sabine Prof. Dr. | |
dc.contributor.thirdReferee | Ritter, Christian O. Prof. Dr. | |
dc.contributor.thirdReferee | Meyer, Thomas Prof. Dr. | |
dc.subject.ger | FDG | de |
dc.subject.ger | PET | de |
dc.subject.ger | CT | de |
dc.subject.ger | Fieber unklarer Genese | de |
dc.subject.ger | FUO | de |
dc.subject.ger | Infektion | de |
dc.subject.ger | Entzündung unklarer Genese | de |
dc.subject.ger | IUO | de |
dc.subject.ger | Vaskulitis | de |
dc.subject.ger | Großgefäßvaskulitis | de |
dc.subject.ger | Riesenzellarteriitis | de |
dc.subject.ger | Takayasu-Arteriitis | de |
dc.subject.ger | Osteomyelitis | de |
dc.subject.ger | Protheseninfektion | de |
dc.subject.eng | FDG | de |
dc.subject.eng | PET | de |
dc.subject.eng | CT | de |
dc.subject.eng | fever of unknown origin | de |
dc.subject.eng | FUO | de |
dc.subject.eng | infection | de |
dc.subject.eng | inflammation of unknown origin | de |
dc.subject.eng | IUO | de |
dc.subject.eng | vasculitis | de |
dc.subject.eng | large vessel vasculitis | de |
dc.subject.eng | giant cell arteritis | de |
dc.subject.eng | Takayasu arteritis | de |
dc.subject.eng | osteomyelitis | de |
dc.subject.eng | infection of hip arthroplasty | de |
dc.subject.eng | infection of knee arthroplasty | de |
dc.identifier.urn | urn:nbn:de:gbv:7-11858/00-1735-0000-002B-7D19-5-6 | |
dc.affiliation.institute | Medizinische Fakultät | de |
dc.subject.gokfull | Radiologie / Bildgebende Verfahren / Ultraschall / Nuklearmedizin / Strahlenschutz - Allgemein- und Gesamtdarstellungen (PPN619875585) | de |
dc.description.embargoed | 2017-02-02 | |
dc.identifier.ppn | 877371288 | |