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Mathematical modeling of the structure and function of inner hair cell ribbon synapses

Gabrielaitis, Mantas
Cumulative thesis
Date of Examination: 2015-12-09
Date of issue: 2017-02-03
Advisor: Wolf, Fred Prof. Dr.
Referee: Wolf, Fred Prof. Dr.
Referee: Moser, Tobias Prof. Dr.
Referee: Jonas, Peter Prof. Dr.

Persistent Address: http://hdl.handle.net/11858/00-1735-0000-002B-7D2F-6

 

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Abstract

English

Information about the auditory world enters the mammalian brain through ribbon synapses of inner hair cells. Due to their fundamental role in auditory processing, these nanoscopic structures have recently received a lot of attention from the research community. The complexity of the system requires to go beyond the standard biological approaches and apply multidisciplinary methods. In this dissertation, a set of contributions to unravel the organization and function of inner hair cell ribbon synapses by using tools of mathematical modeling are presented.
Keywords: hair cell; ribbon synapse; presynaptic active zone; auditory nerve fiber; calcium dynamics; mathematical modeling; stochastic processes
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