Navigation ▼

Show simple item record

dc.contributor.advisor Frahm, Jens Prof. Dr.
dc.contributor.author Zhang, Zhongshuai
dc.date.accessioned 2017-02-09T10:51:17Z
dc.date.available 2017-02-09T10:51:17Z
dc.date.issued 2017-02-09
dc.identifier.uri http://hdl.handle.net/11858/00-1735-0000-002B-7D36-1
dc.language.iso eng de
dc.relation.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc 571.4 de
dc.title Dynamic Temperature Mapping - Real-time Strategies and Model-based Reconstructions de
dc.type doctoralThesis de
dc.contributor.referee Frahm, Jens Prof. Dr.
dc.date.examination 2016-12-14
dc.description.abstracteng The purpose of this thesis was to explore the potential of real-time MRI methods for temperature mapping during thermal procedures. This mainly included a comprehensive analysis of two different methods, i.e. proton resonance frequency (PRF) and T1 thermometry, with respect to speed, robustness, and accuracy in different experimental settings. These methods were chosen because of their pronounced temperature sensitivities and relatively rapid data sampling schemes. Basic implementations and comparisons of suitable data acquisition and image reconstruction strategies were accomplished with use of a home-made temperature phantom. Secondly, PRF thermometry as the resulting preferred method was further analyzed using heating studies of ex vivo tissues. And thirdly, in order to even better mimic clinical thermal therapies, focal heating with use of a laser system was studied on swine kidneys. In both kidney cortex and medulla, the temperature changes for different output powers could be monitored by PRF thermometry in real time. A further development in preparation of future in vivo studies referred to an optimized reference selection procedure in order to minimize temperature errors in the PFR method due to inter-scan motion between the reference and actual scan. Lastly, a model-based reconstruction approach for phase-contrast MRI, which yields temperature maps and anatomic images directly from undersampled raw data sets, has been adopted to the present conditions. Efforts were made especially with respect to temporal regularization to obtain temperature maps with considerably increased quality. de
dc.contributor.coReferee Enderlein, Jörg Prof. Dr.
dc.subject.eng MR thermometry de
dc.subject.eng real-time MRI de
dc.subject.eng nonlinear reconstruction de
dc.subject.eng model-based reconstruction de
dc.subject.eng laser induced thermal therapy de
dc.identifier.urn urn:nbn:de:gbv:7-11858/00-1735-0000-002B-7D36-1-1
dc.affiliation.institute Göttinger Graduiertenschule für Neurowissenschaften, Biophysik und molekulare Biowissenschaften (GGNB) de
dc.subject.gokfull Biologie (PPN619462639) de
dc.identifier.ppn 879426381

Files in this item

This item appears in the following Collection(s)

Show simple item record