Immunadsorption und Plasmapherese in der Behandlung von Multipler Sklerose und Neuromyelitis Optica

Mühlhausen, Johannes

dc.contributor.advisor	Koziolek, Michael Prof. Dr.
dc.contributor.author	Mühlhausen, Johannes
dc.date.accessioned	2017-02-14T13:10:23Z
dc.date.available	2017-03-14T23:50:07Z
dc.date.issued	2017-02-14
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-002B-7D48-A
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-6131
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	610	de
dc.title	Immunadsorption und Plasmapherese in der Behandlung von Multipler Sklerose und Neuromyelitis Optica	de
dc.type	doctoralThesis	de
dc.title.translated	Immunoadsorption and plasmapheresis in treatment of multiple sclerosis and neuromyelitis optica	de
dc.contributor.referee	Koziolek, Michael Prof. Dr.
dc.date.examination	2017-03-07
dc.description.abstracteng	Background: Plasma exchange (PE) and immunoadsorption (IA) are alternative treatments of steroid-refractory relapses of multiple sclerosis (MS) or neuromyelitis optica (NMO). Methods: Adverse events and neurological follow-ups in 127 MS- (62 PE, 65 IA) and 13 NMO- (11 PE, 2 IA) patients were retrospectively analysed. Response was defined by improvements in either expanded disability status scale (EDSS) by at least 1.0 or visual acuity (VA) to 0.5, confirmed after 3 and/or 6 months. Results: 140 patients were included in safety analysis, 102 patients provided sufficient neurological follow-up-data. There were no significant differences between IA and PE in side effects (3.9% vs. 3.6%, p=0.96) or response-rate (p=0.65). Responders showed significant lower age (p=0.02) and earlier apheresis-initiation (p=0.01). Subgroup-analysis confirmed significant lower age in patients with relapsing-remitting MS (RRMS) /clinical isolated syndrome (CIS). Conclusion: IA and PE seem equally safe and effective in steroid-resistant MS- or NMO-relapses. Early apheresis and low patient age are additional prognostic factors.	de
dc.contributor.coReferee	Huppke, Peter Prof. Dr.
dc.subject.ger	Apherese	de
dc.subject.ger	Plasmapherese	de
dc.subject.ger	Immunadsorption	de
dc.subject.ger	Multiple Sklerose	de
dc.subject.ger	Neuromyelitis Optica	de
dc.subject.eng	apheresis	de
dc.subject.eng	immunoadsorption	de
dc.subject.eng	plasma exchange	de
dc.subject.eng	multiple sclerosis	de
dc.subject.eng	neuromyelitis optica	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-002B-7D48-A-1
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Nephrologie (PPN619875828)	de
dc.subject.gokfull	Neurologie - Allgemein- und Gesamtdarstellungen (PPN619876247)	de
dc.description.embargoed	2017-03-14
dc.identifier.ppn	880190353

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