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dc.contributor.advisor Koziolek, Michael Prof. Dr.
dc.contributor.author Mühlhausen, Johannes
dc.date.accessioned 2017-02-14T13:10:23Z
dc.date.available 2017-03-14T23:50:07Z
dc.date.issued 2017-02-14
dc.identifier.uri http://hdl.handle.net/11858/00-1735-0000-002B-7D48-A
dc.language.iso deu de
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc 610 de
dc.title Immunadsorption und Plasmapherese in der Behandlung von Multipler Sklerose und Neuromyelitis Optica de
dc.type doctoralThesis de
dc.title.translated Immunoadsorption and plasmapheresis in treatment of multiple sclerosis and neuromyelitis optica de
dc.contributor.referee Koziolek, Michael Prof. Dr.
dc.date.examination 2017-03-07
dc.description.abstracteng Background: Plasma exchange (PE) and immunoadsorption (IA) are alternative treatments of steroid-refractory relapses of multiple sclerosis (MS) or neuromyelitis optica (NMO).  Methods: Adverse events and neurological follow-ups in 127 MS- (62 PE, 65 IA) and 13 NMO- (11 PE, 2 IA) patients were retrospectively analysed. Response was defined by improvements in either expanded disability status scale (EDSS) by at least 1.0 or visual acuity (VA) to 0.5, confirmed after 3 and/or 6 months. Results: 140 patients were included in safety analysis, 102 patients provided sufficient neurological follow-up-data. There were no significant differences between IA and PE in side effects (3.9% vs. 3.6%, p=0.96) or response-rate (p=0.65). Responders showed significant lower age (p=0.02) and earlier apheresis-initiation (p=0.01). Subgroup-analysis confirmed significant lower age in patients with relapsing-remitting MS (RRMS) /clinical isolated syndrome (CIS). Conclusion: IA and PE seem equally safe and effective in steroid-resistant MS- or NMO-relapses. Early apheresis and low patient age are additional prognostic factors. de
dc.contributor.coReferee Huppke, Peter Prof. Dr.
dc.subject.ger Apherese de
dc.subject.ger Plasmapherese de
dc.subject.ger Immunadsorption de
dc.subject.ger Multiple Sklerose de
dc.subject.ger Neuromyelitis Optica de
dc.subject.eng apheresis de
dc.subject.eng immunoadsorption de
dc.subject.eng plasma exchange de
dc.subject.eng multiple sclerosis de
dc.subject.eng neuromyelitis optica de
dc.identifier.urn urn:nbn:de:gbv:7-11858/00-1735-0000-002B-7D48-A-1
dc.affiliation.institute Medizinische Fakultät de
dc.subject.gokfull Nephrologie (PPN619875828) de
dc.subject.gokfull Neurologie - Allgemein- und Gesamtdarstellungen (PPN619876247) de
dc.description.embargoed 2017-03-14
dc.identifier.ppn 880190353

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