dc.contributor.advisor | Koziolek, Michael Prof. Dr. | |
dc.contributor.author | Mühlhausen, Johannes | |
dc.date.accessioned | 2017-02-14T13:10:23Z | |
dc.date.available | 2017-03-14T23:50:07Z | |
dc.date.issued | 2017-02-14 | |
dc.identifier.uri | http://hdl.handle.net/11858/00-1735-0000-002B-7D48-A | |
dc.identifier.uri | http://dx.doi.org/10.53846/goediss-6131 | |
dc.language.iso | deu | de |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject.ddc | 610 | de |
dc.title | Immunadsorption und Plasmapherese in der Behandlung von Multipler Sklerose und Neuromyelitis Optica | de |
dc.type | doctoralThesis | de |
dc.title.translated | Immunoadsorption and plasmapheresis in treatment of multiple sclerosis and neuromyelitis optica | de |
dc.contributor.referee | Koziolek, Michael Prof. Dr. | |
dc.date.examination | 2017-03-07 | |
dc.description.abstracteng | Background: Plasma exchange (PE) and immunoadsorption (IA) are alternative treatments of steroid-refractory relapses of multiple sclerosis (MS) or neuromyelitis optica (NMO).
Methods: Adverse events and neurological follow-ups in 127 MS- (62 PE, 65 IA) and 13 NMO- (11 PE, 2 IA) patients were retrospectively analysed. Response was defined by improvements in either expanded disability status scale (EDSS) by at least 1.0 or visual acuity (VA) to 0.5, confirmed after 3 and/or 6 months.
Results: 140 patients were included in safety analysis, 102 patients provided sufficient neurological follow-up-data. There were no significant differences between IA and PE in side effects (3.9% vs. 3.6%, p=0.96) or response-rate (p=0.65). Responders showed significant lower age (p=0.02) and earlier apheresis-initiation (p=0.01). Subgroup-analysis confirmed significant lower age in patients with relapsing-remitting MS (RRMS) /clinical isolated syndrome (CIS).
Conclusion: IA and PE seem equally safe and effective in steroid-resistant MS- or NMO-relapses. Early apheresis and low patient age are additional prognostic factors. | de |
dc.contributor.coReferee | Huppke, Peter Prof. Dr. | |
dc.subject.ger | Apherese | de |
dc.subject.ger | Plasmapherese | de |
dc.subject.ger | Immunadsorption | de |
dc.subject.ger | Multiple Sklerose | de |
dc.subject.ger | Neuromyelitis Optica | de |
dc.subject.eng | apheresis | de |
dc.subject.eng | immunoadsorption | de |
dc.subject.eng | plasma exchange | de |
dc.subject.eng | multiple sclerosis | de |
dc.subject.eng | neuromyelitis optica | de |
dc.identifier.urn | urn:nbn:de:gbv:7-11858/00-1735-0000-002B-7D48-A-1 | |
dc.affiliation.institute | Medizinische Fakultät | de |
dc.subject.gokfull | Nephrologie (PPN619875828) | de |
dc.subject.gokfull | Neurologie - Allgemein- und Gesamtdarstellungen (PPN619876247) | de |
dc.description.embargoed | 2017-03-14 | |
dc.identifier.ppn | 880190353 | |