Navigation ▼

Show simple item record

dc.contributor.advisor Lingor, Paul Prof. Dr.
dc.contributor.author Roser, Anna-Elisa
dc.date.accessioned 2017-02-24T09:51:53Z
dc.date.available 2017-02-24T09:51:53Z
dc.date.issued 2017-02-24
dc.identifier.uri http://hdl.handle.net/11858/00-1735-0000-002B-7D59-4
dc.language.iso eng de
dc.relation.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc 570 de
dc.title miRNAs in protection and regeneration of dopaminergic midbrain neurons de
dc.type doctoralThesis de
dc.contributor.referee Lingor, Paul Prof. Dr.
dc.date.examination 2016-04-12
dc.description.abstracteng PD is the second most frequent neurodegenerative disorder affecting over 3 % of the population older than 80 years of age. Although PD is a system disorder which affects most regions of the brain, the progressive demise of the nigrostriatal projections and the inability of this system to regenerate are mainly responsible for the functional deficits observed. The etiology underlying PD is not finally resolved. Recent studies suggest that gene expression regulators might contribute to a large variety of disease states. miRNAs are small non-coding RNAs that are important for the post-transcriptional regulation of gene expression. Alterations in miRNA function have been reported in different neurodegenerative diseases including PD. Furthermore, miRNAs are auspicious therapeutic targets, as the manipulation of their expression might be neuroprotective or could induce the regeneration of neurons. In the present study the miRNAome of developing PMN cultures was analyzed and it was demonstrated that the major changes occur during early development. In order to analyze miRNA expression changes during degeneration and spontaneous regeneration of the murine nigrostriatal system a small RNA sequencing of the midbrain of the 6-OHDA mouse model for PD was performed and revealed novel sets of miRNAs involved in degeneration and regeneration of DA neurons in vivo. Taken together, miRNAs play an important role in development, maintenance and degeneration of DA neurons in vivo and in vitro and thus are promising targets for a better understanding of PD pathophysiology and the development of new therapeutic strategies. de
dc.contributor.coReferee Fischer, André Prof. Dr.
dc.subject.eng miRNA de
dc.subject.eng dopaminergic neurons de
dc.subject.eng neurodegeneration de
dc.subject.eng Parkinson's disease de
dc.subject.eng neuroregeneration de
dc.subject.eng neuroprotection de
dc.identifier.urn urn:nbn:de:gbv:7-11858/00-1735-0000-002B-7D59-4-7
dc.affiliation.institute Göttinger Graduiertenschule für Neurowissenschaften, Biophysik und molekulare Biowissenschaften (GGNB) de
dc.subject.gokfull Biologie (PPN619462639) de
dc.identifier.ppn 880905328

Files in this item

This item appears in the following Collection(s)

Show simple item record