miRNAs in protection and regeneration of dopaminergic midbrain neurons

Roser, Anna-Elisa

dc.contributor.advisor	Lingor, Paul Prof. Dr.
dc.contributor.author	Roser, Anna-Elisa
dc.date.accessioned	2017-02-24T09:51:53Z
dc.date.available	2017-02-24T09:51:53Z
dc.date.issued	2017-02-24
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-002B-7D59-4
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-6153
dc.language.iso	eng	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	570	de
dc.title	miRNAs in protection and regeneration of dopaminergic midbrain neurons	de
dc.type	doctoralThesis	de
dc.contributor.referee	Lingor, Paul Prof. Dr.
dc.date.examination	2016-04-12
dc.description.abstracteng	PD is the second most frequent neurodegenerative disorder affecting over 3 % of the population older than 80 years of age. Although PD is a system disorder which affects most regions of the brain, the progressive demise of the nigrostriatal projections and the inability of this system to regenerate are mainly responsible for the functional deficits observed. The etiology underlying PD is not finally resolved. Recent studies suggest that gene expression regulators might contribute to a large variety of disease states. miRNAs are small non-coding RNAs that are important for the post-transcriptional regulation of gene expression. Alterations in miRNA function have been reported in different neurodegenerative diseases including PD. Furthermore, miRNAs are auspicious therapeutic targets, as the manipulation of their expression might be neuroprotective or could induce the regeneration of neurons. In the present study the miRNAome of developing PMN cultures was analyzed and it was demonstrated that the major changes occur during early development. In order to analyze miRNA expression changes during degeneration and spontaneous regeneration of the murine nigrostriatal system a small RNA sequencing of the midbrain of the 6-OHDA mouse model for PD was performed and revealed novel sets of miRNAs involved in degeneration and regeneration of DA neurons in vivo. Taken together, miRNAs play an important role in development, maintenance and degeneration of DA neurons in vivo and in vitro and thus are promising targets for a better understanding of PD pathophysiology and the development of new therapeutic strategies.	de
dc.contributor.coReferee	Fischer, André Prof. Dr.
dc.subject.eng	miRNA	de
dc.subject.eng	dopaminergic neurons	de
dc.subject.eng	neurodegeneration	de
dc.subject.eng	Parkinson's disease	de
dc.subject.eng	neuroregeneration	de
dc.subject.eng	neuroprotection	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-002B-7D59-4-7
dc.affiliation.institute	Göttinger Graduiertenschule für Neurowissenschaften, Biophysik und molekulare Biowissenschaften (GGNB)	de
dc.subject.gokfull	Biologie (PPN619462639)	de
dc.identifier.ppn	880905328

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GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften [1112]
GGNB - Göttingen Graduate Center for Neurosciences, Biophysics and Molecular Biosciences

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