Ultrastructural characterization of human thigh lymphatic collectors

Hasselhof, Viktoria

dc.contributor.advisor	Wilting, Jörg Prof. Dr.
dc.contributor.author	Hasselhof, Viktoria
dc.date.accessioned	2018-01-04T09:59:53Z
dc.date.available	2018-01-31T23:50:42Z
dc.date.issued	2018-01-04
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-002E-E30C-4
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-6649
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-6649
dc.language.iso	eng	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	610	de
dc.title	Ultrastructural characterization of human thigh lymphatic collectors	de
dc.type	doctoralThesis	de
dc.contributor.referee	Kretschmer, Lutz Prof. Dr.
dc.date.examination	2018-01-24
dc.description.abstracteng	Lymphedema is a condition that affects millions of patients worldwide. Most of the research has been performed on animals, while the cellular and molecular characteristics of human lymphatic collectors have been largely unknown. I studied epifascial lymphtatic collectors of the human thigh. These were isolated during autologous transplantation operations. My transmission electron microscopic studies revealed interstitial Cajal-like cells that are in close contact with smooth muscle cells, possessing multiple caveolae at the contact sites. These interstitial Cajal-like cells are highly ramified, have long processes, caveolae, and lack a basal lamina. I observed two types of smooth muscle cells in the media of the collectors with dark and light cytoplasm, as well as vasa vasorum in the media of the largest collectors. Researching the structure of lymphatic collectors is the basis of possible future pharmacological therapies for lymphedema.	de
dc.contributor.coReferee	Schön, Margarete Prof. Dr.
dc.subject.eng	Lymphatics	de
dc.subject.eng	TEM	de
dc.subject.eng	Lymphedema	de
dc.subject.eng	ICLC	de
dc.subject.eng	Cajal-like	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-002E-E30C-4-1
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Medizin (PPN619874732)	de
dc.subject.gokfull	Anatomie / Histologie / Embryologie / Medizinische Anthropologie - Allgemein- und Gesamtdarstellungen (PPN619875208)	de
dc.description.embargoed	2018-01-31
dc.identifier.ppn	101027953X

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Human- und Zahnmedizin [2871]

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