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dc.contributor.advisor Wilting, Jörg Prof. Dr.
dc.contributor.author Hasselhof, Viktoria
dc.date.accessioned 2018-01-04T09:59:53Z
dc.date.available 2018-01-31T23:50:42Z
dc.date.issued 2018-01-04
dc.identifier.uri http://hdl.handle.net/11858/00-1735-0000-002E-E30C-4
dc.language.iso eng de
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc 610 de
dc.title Ultrastructural characterization of human thigh lymphatic collectors de
dc.type doctoralThesis de
dc.contributor.referee Kretschmer, Lutz Prof. Dr.
dc.date.examination 2018-01-24
dc.description.abstracteng Lymphedema is a condition that affects millions of patients worldwide. Most of the research has been performed on animals, while the cellular and molecular characteristics of human lymphatic collectors have been largely unknown. I studied epifascial lymphtatic collectors of the human thigh. These were isolated during autologous transplantation operations. My transmission electron microscopic studies revealed interstitial Cajal-like cells that are in close contact with smooth muscle cells, possessing multiple caveolae at the contact sites. These interstitial Cajal-like cells are highly ramified, have long processes, caveolae, and lack a basal lamina. I observed two types of smooth muscle cells in the media of the collectors with dark and light cytoplasm, as well as vasa vasorum in the media of the largest collectors. Researching the structure of lymphatic collectors is the basis of possible future pharmacological therapies for lymphedema.  de
dc.contributor.coReferee Schön, Margarete Prof. Dr.
dc.subject.eng Lymphatics de
dc.subject.eng TEM de
dc.subject.eng Lymphedema de
dc.subject.eng ICLC de
dc.subject.eng Cajal-like de
dc.identifier.urn urn:nbn:de:gbv:7-11858/00-1735-0000-002E-E30C-4-1
dc.affiliation.institute Medizinische Fakultät de
dc.subject.gokfull Medizin (PPN619874732) de
dc.subject.gokfull Anatomie / Histologie / Embryologie / Medizinische Anthropologie - Allgemein- und Gesamtdarstellungen (PPN619875208) de
dc.description.embargoed 2018-01-31
dc.identifier.ppn 101027953X

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