Die Rolle des ko-stimulatorischen Moleküls CD28 in verschiedenen Phasen der EAE

The role of the co-stimulating molecule CD28 in different phases of EAE

by Johannes Hufschmidt
Doctoral thesis
Date of Examination:2018-01-25
Date of issue:2018-01-17
Advisor:PD Dr. Fred Lühder
Referee:PD Dr. Fred Lühder
Referee:Prof. Dr. Holger Reichardt
Persistent Address: http://dx.doi.org/10.53846/goediss-6671

 

 

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Abstract

English

This dissertation summarizes the different effects of the co-stimulating molecule CD28 in different phases of EAE, especially regarding the effects on activation markers (e.g. CD44), pro-inflammatory cytokines (like IFN-y and IL-17), on proliferation of T cells, the clinical course of EAE and the role of regulatory T cells.
Keywords: EAE; CD28; co-stimulation; MS; Multiple sclerosis; neuroinflammation
 
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