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dc.contributor.advisor Wirths, Oliver Prof. Dr.
dc.contributor.author Reinert, Jochim
dc.date.accessioned 2018-01-24T10:07:58Z
dc.date.available 2018-02-01T23:50:43Z
dc.date.issued 2018-01-24
dc.identifier.uri http://hdl.handle.net/11858/00-1735-0000-002E-E331-E
dc.language.iso eng de
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc 610 de
dc.title C-terminally truncated Amyloid-β peptides in Alzheimer’s dementia: Deposition of Aβ37, Aβ38, and Aβ39 in the brains of patients with sporadic and familiar Alzheimer’s dementia and in transgenic mouse models. de
dc.type doctoralThesis de
dc.contributor.referee Wirths, Oliver Prof. Dr.
dc.date.examination 2018-01-25
dc.description.abstracteng Alzheimer's dementia is a devastating neurodegenerative disease characterized by profound neuropathological changes of the brain. Imbalances in the production of aggregation-prone Amyloid-Beta Peptides are believed to play a pivotal role in disease pathogenesis. These peptides are generated by subsequent proteolysis of the Amyloid Precursor Protein by a Beta and a Gamma-Sekretase. This Proteolysis yields peptides of differing length with varying C-termini. While the presumably most toxic species Abeta42 and the most produced species Abeta40 have been subject to intensive research, C-terminally truncated Peptides have not received much attention. This study investigates the contribution of Abeta37, Abeta38, and Abeta39 to the neuropathological changes in sporadic and familial Alzheimer's dementia. C-terminally truncated Abeta peptides were found to be deposited primarily to the vasculature in sporadic cases, while familial cases presented more intense depositions that included neuritic plaques. Moreover, this study analyzed commonly employed transgenic mouse models for depositions of the C-terminally truncated Abeta peptides. de
dc.contributor.coReferee Stadelmann-Nessler, Christine Prof. Dr.
dc.subject.eng Alzheimer's dementia de
dc.subject.eng Cerebral amyloid angiopathy de
dc.subject.eng Abeta38 de
dc.subject.eng Abeta37 de
dc.subject.eng Abeta39 de
dc.identifier.urn urn:nbn:de:gbv:7-11858/00-1735-0000-002E-E331-E-7
dc.affiliation.institute Medizinische Fakultät de
dc.subject.gokfull Medizin (PPN619874732) de
dc.description.embargoed 2018-02-01
dc.identifier.ppn 101155173X

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