Prävalenz und Korrelation von Parametern der Risikostratifizierung für den plötzlichen Herztod im ICD-Patientenkollektiv

Hohmann, Christian Holger

dc.contributor.advisor	Zabel, Markus Prof. Dr.
dc.contributor.author	Hohmann, Christian Holger
dc.date.accessioned	2018-01-26T10:22:03Z
dc.date.available	2018-02-19T23:50:45Z
dc.date.issued	2018-01-26
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-002E-E338-F
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-6696
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-6696
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	610	de
dc.title	Prävalenz und Korrelation von Parametern der Risikostratifizierung für den plötzlichen Herztod im ICD-Patientenkollektiv	de
dc.type	doctoralThesis	de
dc.title.translated	Prevalence and correlation of risk stratifiers for sudden cardiac death in patients with ICD	de
dc.contributor.referee	Zabel, Markus Prof. Dr.
dc.date.examination	2018-02-12
dc.description.abstracteng	Sudden cardiac death (SCD) is a common cause of death and appears about 70.000 times a year in Germany. Implantable cardioverter defibrillators (ICDs) are an important treatment. Many people with ICD never receive an appropriate shock. For patient saftey and reduction of costs new risk stratifiers are needed. Feasibility and frequency of pathologic values of risk stratifiers like Microvolt T-Wave Alternans (MTWA), NT-proBNP and Holter Variables (Heart Rate Variability [HRV], Heart Rate Turbulence[HRT], Deceleration Capacity [DC], PVC, VT) are being investigated and correlated with each other. In conclusion there was a high frequency of pathologic values of NT-proBNP, MTWA, HRV, HRT, DC, VES and VT in this high risk population. Non-negative MTWA results correlated strongly with parameters of heart failure. The data indicates that there may be an interaction between TWA and HRT with autonomic nervous system. Fort he first time it was possible to show that HRV is completely independent from TWA results in ICD-patients probably because of less vagal influence on myocardial repolarization. All parameters of HRV correlate with each other except of LF/HF. Determination of all results might not more be necessary. The Deceleration Capacity, a rather new risk stratifier, needs more examination. DC showed a correlation to almost all other stratifiers except SDNN. Therefore several (patho-)physiological processes seem to have impact on the Deceleration Capacity. Further studies are needed to examine these stratifiers (in combination) in order for an outcome to be determined.	de
dc.contributor.coReferee	Krause, Ulrich PD Dr.
dc.contributor.thirdReferee	Danner, Bernhard Prof. Dr.
dc.subject.ger	plötzlicher Herztod	de
dc.subject.ger	Herzfrequenzturbulenz	de
dc.subject.ger	NT-proBNP	de
dc.subject.ger	Herzfrequenzvariabilität	de
dc.subject.eng	sudden cardiac death	de
dc.subject.eng	Heart Rate Variability	de
dc.subject.eng	T-Wave Alternans	de
dc.subject.eng	Heart Rate Turbulence	de
dc.subject.eng	autonomic nervous system	de
dc.subject.eng	NT-proBNP	de
dc.subject.eng	Deceleration Capacity	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-002E-E338-F-8
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Diagnostik {Medizin} (PPN619875739)	de
dc.description.embargoed	2018-02-19
dc.identifier.ppn	1011714566

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