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Korrelation der p53-, EGFR- und SGLT1-Expression im histopathologischen Präparat mit den Nebenwirkungen und dem Outcome einer primären Radio(chemo)Therapie bei Patienten mit lokal fortgeschrittenem Kopf-Hals-Tumor

dc.contributor.advisorWolff, Hendrik PD Dr.
dc.contributor.authorStorf, Hannah Siu-Fa
dc.date.accessioned2018-03-12T07:38:29Z
dc.date.available2018-03-19T23:50:03Z
dc.date.issued2018-03-12
dc.identifier.urihttp://hdl.handle.net/11858/00-1735-0000-002E-E37E-2
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-6759
dc.language.isodeude
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc610de
dc.titleKorrelation der p53-, EGFR- und SGLT1-Expression im histopathologischen Präparat mit den Nebenwirkungen und dem Outcome einer primären Radio(chemo)Therapie bei Patienten mit lokal fortgeschrittenem Kopf-Hals-Tumorde
dc.typedoctoralThesisde
dc.title.translatedCorrelation of p53-, EGFR and SGLT1-Expression in biopsies of locally advanced, inoperable head and neck cancer with the toxicity and the outcome of a primary radio(chemo)therapy)de
dc.contributor.refereeWolff, Hendrik PD Dr.
dc.date.examination2018-03-13
dc.description.abstractengPurpose: To test for a possible correlation between the expression of p53, EGFR and SGLT1 in biopsies of locally advanced, inoperable head and neck cancer with the toxicitiy and the outcome of a primary radio(cehmo) therapy Patients and Methods: from 1994 to 2011, 233 HNSCC patients were treated with radio(chemo)therapy in primary approach. They recevied a normofractionated (2Gy/fraction) irradiation inculuding associted nodal drainage sites to a cumulative dose of 70 Gy. 170 patients received additional concominant chemotherapy (93 5-Fluoruracil/mitomycin c, 1, mitomycin c, 67 platin-based, 9 cetuximab). Toxicity was monitored weekly according tot he Common Toxicity Criteria during treatment as well as drung the follwo up. The pre-treatment biopsies were formalin-fixed and paraffin embedded, immunhistochemically stained with the antibodies DO-7 (p53), 31G7 (EGFR),N3C3 (SGLT1) and semiquantitavely analysed. Results: No statiscally significant coherency between tthe expression of p53, EGFR or SGLT1 in tumorbiopsies and high-grad toxicity of a primary radiochemotherapie could be found. However there was a statistically significant correlation between cytoplasmatic p53 to dysphagia 0-3 as well as nuclear EGFR and dysphagia as well as nausea. Furthermore the cytoplasmatic expression of p53 as well as the membraneous expression of EGFR showed a statistically significant correlation to the endpoints oft the study (overall survival,locoregninal control). Coclusion :These data could not show a significant coherency between the investigated molecular markers p53, EGFR and SGLT1 and the toxicitiy of a primary radiochemotherapie in patients with high grade HNSCC. As far as the expression of p53 and EGFR is concernd a statistic singificant correlation to overall survival and locoregional control could be shown. Further studies are necessary to detect the molecular mechanisms of treatment toxicity and enable an individualised yet effective treatment regimen.de
dc.contributor.coRefereeSchirmer, Markus PD Dr.
dc.contributor.thirdRefereeMausberg, Rainer Prof. Dr.
dc.subject.gerlokal fortgeschrittene Kopf Hals Tumorede
dc.subject.gerprimäre Radio(chemo)Therapiede
dc.subject.gerp53de
dc.subject.gerEGFRde
dc.subject.gerSGLT1de
dc.subject.englocally advanced, inoperable head and neck cancerde
dc.subject.engprimary radio(chemo) therapyde
dc.subject.engp53de
dc.subject.engEGFRde
dc.subject.engSGLT1de
dc.identifier.urnurn:nbn:de:gbv:7-11858/00-1735-0000-002E-E37E-2-4
dc.affiliation.instituteMedizinische Fakultätde
dc.subject.gokfullRadiologie / Bildgebende Verfahren / Ultraschall / Nuklearmedizin / Strahlenschutz - Allgemein- und Gesamtdarstellungen (PPN619875585)de
dc.description.embargoed2018-03-19
dc.identifier.ppn1015725627


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