| dc.contributor.advisor | Nauck, Michael A. Prof. Dr. | |
| dc.contributor.author | Haase, Maike | |
| dc.date.accessioned | 2018-03-20T06:59:52Z | |
| dc.date.available | 2018-03-22T23:50:11Z | |
| dc.date.issued | 2018-03-20 | |
| dc.identifier.uri | http://hdl.handle.net/11858/00-1735-0000-002E-E391-3 | |
| dc.identifier.uri | http://dx.doi.org/10.53846/goediss-6772 | |
| dc.language.iso | deu | de |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject.ddc | 610 | de |
| dc.title | Vergleich von zwei Protokollen zur Durchführung eines Fastentages zur Überprüfung der basalen Insulinsubstitution bei Typ-1-Diabetes: Konsequentes Fasten im Vergleich zur Erlaubnis einer Kost mit vernachlässigbarem Kohlenhydrat- und Kaloriengehalt | de |
| dc.type | doctoralThesis | de |
| dc.title.translated | Comparison of basal rate tests (24-hour fasts) performed in type-1-diabetic subjects with either absolute fasting or snacks containing negligible carbohydrate amounts | de |
| dc.contributor.referee | Nauck, Michael A. Prof. Dr. | |
| dc.date.examination | 2018-03-20 | |
| dc.description.abstracteng | Aims: Basal rate tests (24-hour fasting periods) may be necessary to optimize basal insulin
replacement in type 1 diabetes. It was the aim of this study to prospectively compare the
allowance of negligible carbohydrate snacks vs absolute fasting.
Methods: A total of 20 patients with type 1 diabetes (age, 48 ± 15 years (9 women, 11 men);
BMI, 28.5 ± 4.5 kg/m2; HbA1c, 8.8% ± 2.0% (73.0 ± 21.9 mmol/mol); insulin dose,
0.69 ± 0.31 IU/kg body weight and per day) participated in 2 basal rate tests lasting 24 hours
in random order with unchanged basal insulin replacement. On 1 occasion, negligible carbohydrate
snacks (salads and vegetables, up to 5.1 g carbohydrate and 276.3 kJ per portion) were
allowed; during the second test subjects were obliged to fast absolutely. Plasma glucose profiles
were determined using an exact laboratory method. Hypoglycaemic episodes (plasma glucose
< 70 mg/dL) were compared.
Results: Plasma glucose concentrations during fasting periods, with and without negligible carbohydrate
snacks, did not differ significantly (P = .65) and differences were negligible (95%
confidence intervals always included a difference of 0 mmol/L). Also, there was no difference
in the number of hypoglycaemic plasma glucose values (P = .40) or in compensatory carbohydrate
intake. Basal rate testing with negligible carbohydrate snacks was better tolerated (questionnaire,
P = .046) and the desire to discontinue the fasting period was significantly
reduced (P = .023).
Conclusions: Allowing negligible carbohydrate snacks results in unchanged plasma glucose profiles
during basal rate testing and is better tolerated by patients with type 1 diabetes. | de |
| dc.contributor.coReferee | Raddatz, Dirk Prof. Dr. | |
| dc.contributor.thirdReferee | Oppermann, Martin Prof. Dr. | |
| dc.subject.eng | basal insulin replacement | de |
| dc.subject.eng | basal rate test | de |
| dc.subject.eng | fasting | de |
| dc.subject.eng | hypoglycaemia | de |
| dc.subject.eng | intensified insulin regimen | de |
| dc.subject.eng | multiple daily insulin injections | de |
| dc.subject.eng | type 1 diabetes | de |
| dc.identifier.urn | urn:nbn:de:gbv:7-11858/00-1735-0000-002E-E391-3-2 | |
| dc.affiliation.institute | Medizinische Fakultät | de |
| dc.subject.gokfull | Diagnostik {Medizin} (PPN619875739) | de |
| dc.description.embargoed | 2018-03-20 | |
| dc.identifier.ppn | 101620003X | |