Etablierung und Charakterisierung eines experimentellen Modells für invasive Gliome

Establishment and characterization of an experimental model for invasive gliomas

by Christoph Richter
Doctoral thesis
Date of Examination:2018-04-05
Date of issue:2018-04-04
Advisor:Prof. Dr. Hans-Christoph Ludwig
Referee:Prof. Dr. Hans-Christoph Ludwig
Referee:Prof. Dr. Christof Kramm
Persistent Address: http://dx.doi.org/10.53846/goediss-6819

 

 

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Abstract

English

Gliomas belong to the most malignant cancers we know. It is accepted that origin of the disease and glioma progression is caused by glioma-initiating cells (GICs). These cells have stem-cell attributes and are thought to provide target for new therapeutic options. GIC`s still lack of reliable markers to be identified in the heterogenous Tumors. This study examines glioma cell line G112 in vitro and in vivo. Stem-cell attributes are investigated in vitro. A very invasive phenotype and radioresistance have been verified in an orthotopic model. A reliable model for invasive gliomas has been established and has been characterized for the first time.
Keywords: Glioma
Schlagwörter: Glioblastom
 
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