Etablierung und Charakterisierung eines experimentellen Modells für invasive Gliome

Etablierung und Charakterisierung eines experimentellen Modells für invasive Gliome

Establishment and characterization of an experimental model for invasive gliomas

Christoph Richter

Doctoral thesis

Date of Examination: 2018-04-05

Date of issue: 2018-04-04

Advisor: Ludwig, Hans-Christoph Prof. Dr.

Referee: Ludwig, Hans-Christoph Prof. Dr.

Referee: Kramm, Christof Prof. Dr.

Persistent Address: http://hdl.handle.net/11858/00-1735-0000-002E-E3AA-D

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Abstract

English

Gliomas belong to the most malignant cancers we know. It is accepted that origin of the disease and glioma progression is caused by glioma-initiating cells (GICs). These cells have stem-cell attributes and are thought to provide target for new therapeutic options. GIC`s still lack of reliable markers to be identified in the heterogenous Tumors. This study examines glioma cell line G112 in vitro and in vivo. Stem-cell attributes are investigated in vitro. A very invasive phenotype and radioresistance have been verified in an orthotopic model. A reliable model for invasive gliomas has been established and has been characterized for the first time.

Keywords: Glioma

Schlagwörter: Glioblastom