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dc.contributor.advisor Staiger, Jochen Prof. Dr.
dc.contributor.author Narayanan, Ramanathan
dc.date.accessioned 2018-04-10T09:11:57Z
dc.date.available 2018-04-10T09:11:57Z
dc.date.issued 2018-04-10
dc.identifier.uri http://hdl.handle.net/11858/00-1735-0000-002E-E3B3-8
dc.language.iso eng de
dc.relation.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc 570 de
dc.title BAF155 regulates the genesis of basal progenitors through both Pax6-dependent and independent mechanisms during cerebral cortex development de
dc.title.alternative Role of BAF155 and PAX6 in cortical development de
dc.type doctoralThesis de
dc.contributor.referee Fischer, André Prof. Dr.
dc.date.examination 2017-07-28
dc.description.abstracteng During mammalian development, the balance between symmetric and asymmetric division of radial glial (RG) progenitors regulates the tangential size versus radial growth of the cerebral cortex. The pool of basal progenitors (BPs) that contribute to radial growth have expanded greatly during evolution and studies in the past have identified several underlying key transcriptional and signalling mechanisms. In this study, we found that the interaction between BAF155 subunit of the mSWI/SNF chromatin-remodeling complex and Pax6, a key transcriptional regulator of corticogenesis, controls the fate choice of mouse RG specifically during early cortical development. Besides a cell-autonomous role in regulating RG division, we also found that the loss of BAF155 and Pax6 causes delamination of RG from the VZ to generate basal RG, through a novel CEP4 dependent non cell-autonomous mechanism. Interestingly, our results also suggested that such a non cell-autonomous mechanism of BP genesis might be a hallmark of primate cortical development. de
dc.contributor.coReferee Nave, Klaus-Armin Prof. Dr.
dc.subject.eng Cortical development de
dc.subject.eng Basal progenitors de
dc.subject.eng BAF155 de
dc.subject.eng PAX6 de
dc.subject.eng Chromatin remodeling de
dc.identifier.urn urn:nbn:de:gbv:7-11858/00-1735-0000-002E-E3B3-8-8
dc.affiliation.institute Göttinger Graduiertenschule für Neurowissenschaften, Biophysik und molekulare Biowissenschaften (GGNB) de
dc.subject.gokfull Biologie (PPN619462639) de
dc.identifier.ppn 1018321721

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