Vaskuläres Regenerationspotential im Muskel und endotheliale Vorläuferzellen im Blut bei Patienten mit Myositis

Lemmer, Dana

dc.contributor.advisor	Patschan, Susann PD Dr.
dc.contributor.author	Lemmer, Dana
dc.date.accessioned	2018-05-28T10:23:19Z
dc.date.available	2018-06-13T22:50:06Z
dc.date.issued	2018-05-28
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-002E-E3FA-C
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-6861
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-6861
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	610	de
dc.title	Vaskuläres Regenerationspotential im Muskel und endotheliale Vorläuferzellen im Blut bei Patienten mit Myositis	de
dc.type	doctoralThesis	de
dc.title.translated	Vascular Regeneration Potential in Muscle and Endothelial Progenitor Cells in Blood of Patients with Myositis	de
dc.contributor.referee	Patschan, Susann PD Dr.
dc.date.examination	2018-06-06
dc.description.abstracteng	The pathogenesis of dermatomyositis (DM) is believed to rely on humeral mechanisms, whereas the hypothesized cause of polymyositis (PM) are cytotoxic T cells. Necrotizing myopathy (NM) is histopathologically characterized by necrosis of muscle fibres in absence of inflammation. Vascular pathology includes depositions of complement in the case of NM and DM. The latter is characterized by capillary reduction and destruction. Aim of this project was to analyse the presence and functional alteration of early Endothelial Progenitor Cells (eEPCs) in blood and of relevant markers in muscle biopsies in DM, PM and NM. Blood-derived eEPC colonies were significantly lower in NM, DM and PM as compared to healthy controls. Percentages of peripheral circulating eEPCs (CD133+/VEGFR-2+) showed a lowering tendency in DM and PM. Staining of muscle biopsies revealed strong signals for vascular CXCR6 in DM, NM and PM. The number of capillaries counted via CD31 was significantly reduced in the DM and PM group. Angiogenic mediators showed significantly strong signals for CXCL16 in all myopathies. The data suggest that (I) vascular damage and eEPC mechanisms are involved in all three types of myositis. (II) Higher abundances of vascular CXCR6 and blood derived CXCL16 suggest eEPC recruitment. (III) These data contribute to a better understanding of the pathogenesis of idiopathic inflammatory myopathies (IIM).	de
dc.contributor.coReferee	Schmidt, Jens Prof. Dr.
dc.subject.eng	myositis	de
dc.subject.eng	endothelial progenitor cells	de
dc.subject.eng	EPCs	de
dc.subject.eng	idiopathic inflammatory myopathy	de
dc.subject.eng	dermatomyositis	de
dc.subject.eng	polymyositis	de
dc.subject.eng	necrotizing myopathy	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-002E-E3FA-C-6
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Rheumatologie (PPN619875887)	de
dc.description.embargoed	2018-06-13
dc.identifier.ppn	1023361078

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Human- und Zahnmedizin [2870]

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