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Manipulation of the Working Memory Performance in Humans using Transcranial Alternating Current Stimulation over the Frontoparietal Network

dc.contributor.advisorAntal, Andrea Prof. Dr.
dc.contributor.authorPabel, Stefanie Corinna
dc.date.accessioned2018-11-14T09:53:17Z
dc.date.available2018-11-22T23:50:05Z
dc.date.issued2018-11-14
dc.identifier.urihttp://hdl.handle.net/11858/00-1735-0000-002E-E4FF-9
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-7141
dc.language.isoengde
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc610de
dc.titleManipulation of the Working Memory Performance in Humans using Transcranial Alternating Current Stimulation over the Frontoparietal Networkde
dc.typedoctoralThesisde
dc.contributor.refereeAntal, Andrea Prof. Dr.
dc.date.examination2018-11-15
dc.description.abstractengThe working memory (WM) is a key mechanism that ensures complex behavior in humans. It requires the bilateral activation of the fronto-parietal brain network and has been subdivided on the phonological loop, which processes numbers, semantics and auditory-verbal information, with lateralized activation towards the left hemisphere, and the visuo-spatial sketchpad, which mainly operates in the right hemisphere (Baddeley and Hitch 1974; Sauseng et al. 2005; Müller and Knight 2006; Baddeley 2012; Eriksson et al. 2015). This neural system maintains constant long-range communications within itself and with other cognitive systems through neuronal oscillations. This work aimed to show a causal relationship between visuo-spatial WM functions and the mechanism of fronto-parietal oscillatory connectivity – the theta phase coherence. To reach our aim, two experiments were conducted. Our first hypothesis was that the WM network operates by phase connectivity. The results of the electroencephalographic (EEG) experiment demonstrated significant theta coherence during the WM events. Our second hypothesis was that it would be feasible to interfere with the WM through bi-hemispheric transcranial alternating current stimulation (tACS) and thus change phase connectivity. To show causal effects of theta coherence, behavioral changes in subjects under fronto-parietal theta-tACS bi-laterally, were analyzed. We found that desynchronization of theta phase relations in the fronto-parietal network led to an impairment in the WM performance. Synchronization of the fronto-parietal network had no significant effect on the group level, but individual analysis revealed a tendency for improvement of the WM for subjects with low baseline performance. These results show that optimally balanced theta coherence in the fronto-parietal network is a prerequisite for the ideal WM functions in humans.de
dc.contributor.coRefereeDechent, Peter PD Dr.
dc.contributor.thirdRefereeMeyer, Thomas Prof. Dr.
dc.subject.engtACSde
dc.subject.engtheta coherencede
dc.subject.engfrontoparietal networkde
dc.subject.engworking memory performancede
dc.subject.engdesynchronizationde
dc.subject.engneuronal oscillationsde
dc.identifier.urnurn:nbn:de:gbv:7-11858/00-1735-0000-002E-E4FF-9-5
dc.affiliation.instituteMedizinische Fakultätde
dc.subject.gokfullPhysiologie / Pathophysiologie - Allgemein- und Gesamtdarstellungen (PPN619875283)de
dc.description.embargoed2018-11-22
dc.identifier.ppn1040528058


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