Zytostatisches Potenzial neuer Uracilderivate

Hofmann, Antje Britta

dc.contributor.advisor	Steinfelder, Hans Jürgen Prof. Dr.
dc.contributor.author	Hofmann, Antje Britta
dc.date.accessioned	2018-11-29T10:14:49Z
dc.date.available	2018-12-12T23:50:05Z
dc.date.issued	2018-11-29
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-002E-E518-7
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-7162
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-7162
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-7162
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	610	de
dc.title	Zytostatisches Potenzial neuer Uracilderivate	de
dc.type	doctoralThesis	de
dc.title.translated	Cytostatic potential of new uracilderivatives	de
dc.contributor.referee	Steinfelder, Hans Jürgen Prof. Dr.
dc.date.examination	2018-12-05
dc.description.abstracteng	In medicine uracil derivatives are already used as antiviral and cytostatic drugs. In this study new uracil derivatives were tested to evaluate their cytostatic and pro-apoptotic potential. Nitrovinyl- and Bromoethynyluracil, used in cell culture on leukaemia/lymphoma cells as und colon cancer cells, showed cytotoxic and pro-apoptotic effects. It could be shown that additional substituents which increased the lipophilic character enhanced cytostatic and pro-apoptotic effects. Moreover it was proven that substances with a free thiol group have a cyto-protective effect under treatment with the new uracil derivatives. Additionally the intracellular content of glutathione as well as the changes under treatment have been evaluated.	de
dc.contributor.coReferee	Kube, Dieter Prof. Dr.
dc.subject.ger	Zytostatisches	de
dc.subject.ger	Potenzial	de
dc.subject.ger	Uracilderivate	de
dc.subject.eng	Cytostatic	de
dc.subject.eng	potential	de
dc.subject.eng	uracilderivatives	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-002E-E518-7-5
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Medizin (PPN619874732)	de
dc.subject.gokfull	Pharmakologie / Toxikologie / Pharmakotherapie - Allgemein- und Gesamtdarstellungen (PPN61987550X)	de
dc.description.embargoed	2018-12-12
dc.identifier.ppn	1041240368

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Human- und Zahnmedizin [2872]

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