Nicht-invasive Risikostratifikation für den plötzlichen Herztod bei Patienten mit angeborenem Herzfehler

Roth, Sabine

dc.contributor.advisor	Zabel, Markus Prof. Dr.
dc.contributor.author	Roth, Sabine
dc.date.accessioned	2018-12-03T14:32:16Z
dc.date.available	2018-12-11T23:50:05Z
dc.date.issued	2018-12-03
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-002E-E520-4
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-7167
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	610	de
dc.title	Nicht-invasive Risikostratifikation für den plötzlichen Herztod bei Patienten mit angeborenem Herzfehler	de
dc.type	doctoralThesis	de
dc.title.translated	Non-invasive Riskstratification for Sudden Cardiac Death in Patients with Congenital Heart Disease	de
dc.contributor.referee	Steinmetz, Michael PD Dr.
dc.date.examination	2018-12-04
dc.description.abstracteng	Background: The assessment of the risk of sudden cardiac death by non-invasive markers is well established for patients with myocardial infarction and ischemic cardiomyopathy. Up to now it has not been investigated for patients with congenital heart disease. Objectives: The aim of this study was to verify if there are similar results of non-invasive risk markers in a pediatric cardiology study population as in patients with myocardial infarction and ischemic cardiomyopathy. Methods: A total of 41 pediatric cardiology patients with a perceived risk for malignant arrhythmias underwent the assessment of late potentials (fQRS, RMS, LAS), T-Wave-Alternans (TWA, max. neg. HR), heart rate variability (HRV, SDNN=standard deviation of RR-intervals), heart rate turbulence (HRT, TO=turbulence onset, TS=turbulence slope) and deceleration capacity. There were two control groups. One group of 16 healthy students and one of 33 post myocardial infarction patients. There also was a mean follow up of 3.6 years for death, resuscitation and appropriate ICD-shocks. Results: The healthy student group had all over normal values. The pediatric cardiology patients displayed pathological findings which were more pronounced in patients with increasing severity of the basic disease. During 3.6 years of mean follow up there was one resuscitation in the pediatric cardiology study cohort and eight deaths and two appropriate ICD-shocks in the post myocardial infarction patients group. Conclusion: The established noninvasive risk markers showed pathological findings in the pediatric cardiology patients. But there were no significant differences associated with endpoints during our long term follow up.	de
dc.contributor.coReferee	Oppermann, Martin Prof. Dr.
dc.subject.ger	angeborener Herzfehler	de
dc.subject.ger	Risikostratifikation	de
dc.subject.ger	plötzlicher Herztod	de
dc.subject.ger	T-Wellen-Alternans	de
dc.subject.ger	Herzfrequenzvariabilität	de
dc.subject.ger	Herzfrequenzturbulenz	de
dc.subject.ger	Spätpotentiale	de
dc.subject.eng	risk stratification	de
dc.subject.eng	sudden cardiac death	de
dc.subject.eng	T-Wave-Alternans	de
dc.subject.eng	heart rate variability	de
dc.subject.eng	heart rate turbulence	de
dc.subject.eng	late potentials	de
dc.subject.eng	congenital heart disease	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-002E-E520-4-9
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Kardiologie (PPN619875755)	de
dc.description.embargoed	2018-12-11
dc.identifier.ppn	1041372507

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Human- und Zahnmedizin [2872]

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