The early Development of the Germline in Drosophila melanogaster

by Andres Hertel
Doctoral thesis
Date of Examination:2018-02-13
Date of issue:2018-12-14
Advisor:Dr. Gerd Vorbrüggen
Referee:Dr. Gerd Vorbrüggen
Referee:Prof. Dr. Ernst A. Wimmer
Persistent Address: http://dx.doi.org/10.53846/goediss-7187

 

 

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Abstract

English

The germline cells are of fundamental importance for all animals as they have the ability to give rise to the next generation. Their precursors, the primordial germ cells (PGCs), are determined very early during animal development. In Drosophila, the PGCs arise from a specialized cytoplasm, the germplasm, which is deposited at the posterior pole of the oocyte during oogenesis. In this thesis two gene functions have been investigated which are required for the early separation of the PGCs from the somatic epithelium. If these gene functions are absent the PGCs migrate through the epithelium prematurely. Both genes have overlapping mutant phenotypes but function using different mechanisms. One gene is essential for the epithelium's ability to prevent untimed PGC migration while the other one affects the RNA-protein particles of the germ plasm.
Keywords: Drosophila; Development; Germline
 
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