Über den Einfluss einer verringerten BRAP-Expression auf die Entwicklung der Atherosklerose im ApoE-defizienten Mausmodell

Sabrow, Moritz Martin

dc.contributor.advisor	Seidler, Tim PD Dr.
dc.contributor.author	Sabrow, Moritz Martin
dc.date.accessioned	2019-02-22T09:45:44Z
dc.date.available	2019-03-06T23:50:04Z
dc.date.issued	2019-02-22
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-002E-E5A2-D
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-7301
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	610	de
dc.title	Über den Einfluss einer verringerten BRAP-Expression auf die Entwicklung der Atherosklerose im ApoE-defizienten Mausmodell	de
dc.type	doctoralThesis	de
dc.title.translated	Effects of a reduced expression of BRAP on the developement of atherosclerosis in ApoE-deficient mice	de
dc.contributor.referee	Seidler, Tim PD Dr.
dc.date.examination	2019-02-27
dc.description.abstracteng	Atherosclerosis is among the leading causes of death in most parts of the world. The aetiology of this wide-spread, multifactorial disease is not yet entirely understood. Identified conventional risk factors include smoking, diabetes mellitus, hypercholesterolaemia and hypertension, but genetic influence is also proving to be an important risk factor. It has been reported that single nucleotide polymorphisms (SNP) in brap are associated with an aggravation of the atherosclerotic burden in certain human populations. Further evidence indicates that one of them leads to an increased expression of BRAP. The aim of this thesis, therefore, was to examine the effects of a reduced expression of BRAP on the development of atherosclerotic plaques in ApoE-knockout mice. For this purpose ApoE-deficient C57BL/6J-mice (ApoE-/-) with a heterozygous knockout of BRAP (IMP+/-) were set on either a high fat diet or a standard diet for 6 months. ApoE-/- IMP+/+ mice set on the same regime served as a control group for the respective diet. All mice were phenotyped and the atherosclerotic lesions at the aortic root as well as in the brachiocephalic artery were measured. Further examination was carried out by immunohistochemial analysis followed by an evaluation for plaque instability. The results indicate that a reduced expression of BRAP in ApoE-/- is not followed by a lesser extent of atherosclerosis. However, ApoE-/- IMP+/--mice show larger abdominal fat pads and have a lower LDL/HDL ratio. This could be an explanation for the observed increased cardiovascular risk associated with an altered expression of BRAP.	de
dc.contributor.coReferee	Bogeski, Ivan Prof Dr.
dc.subject.ger	Atherosklerose	de
dc.subject.ger	Hochfettdiät	de
dc.subject.eng	BRAP	de
dc.subject.eng	IMP	de
dc.subject.eng	atherosclerosis	de
dc.subject.eng	ApoE	de
dc.subject.eng	high fat diet	de
dc.subject.eng	MAPK	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-002E-E5A2-D-3
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Kardiologie (PPN619875755)	de
dc.description.embargoed	2019-03-06
dc.identifier.ppn	1054637601

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Human- und Zahnmedizin [2872]

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