The role of mammalian TRC40 in membrane-protein targeting and chaperoning

Coy Vergara, Francisco Javier

dc.contributor.advisor	Schwappach, Blanche Prof. Dr.
dc.contributor.author	Coy Vergara, Francisco Javier
dc.date.accessioned	2019-05-24T08:37:09Z
dc.date.available	2019-05-24T08:37:09Z
dc.date.issued	2019-05-24
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-002E-E649-F
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-7455
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-7455
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-7455
dc.language.iso	eng	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	572	de
dc.title	The role of mammalian TRC40 in membrane-protein targeting and chaperoning	de
dc.type	doctoralThesis	de
dc.contributor.referee	Schwappach, Blanche Prof. Dr.
dc.date.examination	2018-06-04
dc.description.abstracteng	Tail-anchored (TA) proteins are distinguished from other membrane proteins due to their particular topology. The best-characterized pathway for the targeting of TA-proteins is the GET pathway in yeast or the TRC pathway in mammals. Recently, several studies have reported that more than one post-translational pathway operate during targeting of TA-proteins to the ER-membrane such as the EMC pathway, Hsp40/Hsc70, the SND pathway and the PEX pathway. TRC40 is the cytoplasmic effector of the TRC pathway. This study aims to investigate the reliance of TA-proteins on the TRC pathway at the steady-state in vivo in mammalian cells. Moreover, the role of several functional domains of TRC40 during TA-proteins targeting to ER membrane and chaperoning in vivo is addressed in this study. Furthermore, this study wants to explore the potential alternative role of TRC40 as redox-regulated chaperone.	de
dc.contributor.coReferee	Kessel, Michael Prof. Dr.
dc.contributor.thirdReferee	Raimundo, Nuno Dr.
dc.contributor.thirdReferee	Meinecke, Michael Prof. Dr.
dc.contributor.thirdReferee	Schmitt, Hans Dieter Dr.
dc.contributor.thirdReferee	Kehlenbach, Ralph Prof. Dr.
dc.subject.eng	TRC40	de
dc.subject.eng	TRC pathway	de
dc.subject.eng	Client spectrum	de
dc.subject.eng	Chaperone	de
dc.subject.eng	Tail-anchored proteins	de
dc.subject.eng	TA-proteins	de
dc.subject.eng	Trap	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-002E-E649-F-0
dc.affiliation.institute	Göttinger Graduiertenschule für Neurowissenschaften, Biophysik und molekulare Biowissenschaften (GGNB)	de
dc.subject.gokfull	Biologie (PPN619462639)	de
dc.identifier.ppn	1666651567

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GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften [1115]
GGNB - Göttingen Graduate Center for Neurosciences, Biophysics and Molecular Biosciences

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