Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Nave, Klaus-Armin Prof. Dr."
Now showing items 1-20 of 33
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A novel role for the E3 ubiquitin ligase FBXO7 in axon-myelin interaction
(2018-06-06)The regulated turnover of proteins is an essential aspect of every cell. Cells must be able to respond to environmental changes or undergo different developmental stages, while still maintaining a balanced protein homeostasis. ... -
Actin turnover regulates mechanical properties of oligodendrocytes and myelin formation
(2015-10-02)The myelin sheath is a specialized membranous structure that facilitates rapid signal conduction along axonal segments. During central nervous system development, it is formed by oligodendrocytes that extend motile and ... -
Ageing-associated myelin dysfunction as a driver of amyloid deposition in Alzheimer’s disease
(2022-01-07)Alzheimer’s disease (AD) is the most common neurodegenerative disease with increasing prevalence due to longer lifespans in the human population. AD manifests as various age-associated cognitive impairments summarised under ... -
Assessment of Epigenetic profile in Alzheimer's disease
(2012-11-30)Alzheimer's disease is caused by multivariate factors with a convergent insult to neuronal integrity leading to cognitive decline and neurodegeneration. To develop an efficient therapeutic strategy for treatment of AD calls ... -
BACE1 dependent function of Neuregulin1 in peripheral nervous system myelination
(2010-05-26)The neuronal epidermal growth factor (EGF)-like growth factor NRG1 type III serves as a master regulator of myelination in the peripheral nervous system (PNS). It has been proposed that ... -
BAF155 regulates the genesis of basal progenitors through both Pax6-dependent and independent mechanisms during cerebral cortex development
(2018-04-10)During mammalian development, the balance between symmetric and asymmetric division of radial glial (RG) progenitors regulates the tangential size versus radial growth of the cerebral cortex. The pool of basal progenitors ... -
Combining induced protease fragment assembly and microarray analysis to monitor signaling in living cells.
(2009-11-19)The ability to monitor multiple signaling events simultaneously in living cells is essential to better understand complex biological processes. So far, DNA-microarray technologies provide ... -
Dynamic regulation of myelin genes in wild type and SHARP1 and -2 double null-mutant mice
(2013-12-19)In living organisms, a molecular clockwork synchronises physiological mechanisms with daily recurrent changes in the environment, a process that is termed entrainment. The two basic helix-loop-helix (bHLH) transcription ... -
Erythropoietin as a driver of neurodifferentiation, neuroplasticity and cognition – A continuum view of the neuronal lineage
(2019-12-05)Erythropoietin (EPO), named after its role in hematopoiesis, has been best studied in the hematopoietic system. Studies emphasizing the expression of EPO in the central nervous system have sparked an interest in its role ... -
Establishing parameters for the characterization of rare neurometabolic and neurodegenerative diseases using mass-spectrometry based Metabolomics
(2021-10-18)Rare diseases are a class of disorders where every single disease has a low prevalence, but due to their incredible variety, they affect more than 100 million people worldwide. A significant number of these disorders lead ... -
Evaluating the function of the Aryl Hydrocarbon Receptor in CNS autoimmunity
(2018-12-07)The aryl hydrocarbon receptor (AhR) is a ligand activated transcription factor highly expressed within the immune and nervous system. Structurally diverse endogenous and synthetic ligands activate AhR, including dietary, ... -
Exploring the neural basis of touch through selective and stable genetic tagging in the chick somatosensory system
(2013-01-03)The assembly of circuitries for somatosensory perception relies on a complex interplay of neuronal diversification, specification, phenotypic modulation and establishment of precise connectivity patterns during embryogenesis. ... -
Genetic and autoimmune modulators of brain function in neuropsychiatric illness and health
(2018-06-15)In the present thesis, the synergetic interaction between the nervous and immune systems and the potential pathological outcomes mediated by autoimmune processes targeting the brain was addressed, with a particular focus ... -
Grey matter pathology in multiple sclerosis
(2006-01-30)Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. MS has traditionally been considered a disease affecting the well myelinated white matter ... -
Huntingtin toxicity is ameliorated by BAG1 through modulation of its aggregation, degradation and subcellular distribution
(2009-02-23)Huntington s disease (HD) is a fatal neurodegenerative disorder resulting from an expansion of a polyglutamine stretch in a ubiquitously expressed protein called huntingtin. Intraneuronal ... -
Investigation of Sip1 gene interactions in the development of the mammalian telencephalon
(2010-08-02)The transcriptional repressor Sip1, or Smad- interacting protein 1, has been shown to play a key role in early neurodevelopment. Mowat- Wilson Syndrome in humans is associated with mutations ... -
Lysosomal and mitochondrial crosstalk: the role of lysosomal signaling on mitochondrial biogenesis and function
(2018-11-15)Defects in metabolism result in various diseases, with neurodegeneration being one of the most prevalent consequences. Mitochondria and lysosomes are long known to be fundamental for cellular metabolism. In addition to ... -
Molecular correlates of spinal motor neuron functional specification and plasticity
(2013-07-30)The precision with which motor neurons connect to functionally matched muscle fibers ultimately determines the accuracy of behavioural outputs. Motor neurons are functionally diverse and can be subdivided into distinct ... -
Molecular mechanisms of the effect of the mood stabilizer lithium on cAMP-induced CREB transcriptional activity
(2009-07-03)Lithium salts are used now for 60 years to treat bipolar disorder, a chronic, severe and often life-threatening illness characterized by recurrent phases of the two opposing mood states of ... -
Multi-contrast Magnetic Resonance Imaging of Myelin and Iron in the Brain
(2022-09-27)The non-invasive characterization of brain myelin has essential applications in basic neuroscience and the clinical management of white matter brain diseases and other inflammatory and neurodegenerative diseases. Magnetic ...