Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Rizzoli, Silvio Prof. Dr."
Now showing items 1-20 of 36
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Learning-dependent plasticity of the Drosophila mushroom body: An optophysiological approach
(2024-07-29)Functional changes in the neuronal network of our brain enable experience-dependent adaptations to the environment through our behavior, referred to as learning and memory. One fundamental topic has occupied the neurosciences ... -
Investigations of Synaptic Alterations in Models of Parkinson’s Disease
(2024-07-02)Alpha-synuclein (aSyn) is a presynaptic protein implicated in physiological synaptic roles, though its precise function is largely unknown. In Parkinson's disease (PD), the initial pathological events often involve synaptic ... -
Investigation of a putative circuit in the mouse retina
(2024-06-27)Retinal ganglion cells of the vertebrate retina are tuned to detect specific features of the visual scene and effectively decompose it into different channels that are transmitted to and used by the brain to create the ... -
Saynpatic mechanisms of noise-induced hearing loss
(2024-04-19)Noise-induced hearing loss (NIHL) is a form of acquired hearing impairment, caused by exposure to loud noise, that damages the delicate inner ear structures, possibly including the neural connections between the Inner Hair ... -
Quantitative molecular physiology at active zones of calyceal synapses of the auditory pathway
(2023-11-17)Bushy cells (BCs) of the anteroventral cochlear nucleus (aVCN) are the first relay station of ascending auditory information. Sound is transformed from mechanical to electrical stimuli by the inner hair cells of the cochlea ... -
Illuminating the Morphological and Functional Plasticity of the Cochlear Inner Hair Cell Ribbon Synapse
(2023-10-24)Sound detection occurs in the cochlea, where sensory inner hair cells (IHC) accurately convert auditory stimuli into a neurochemical signal. Presynaptically, cochlear IHCs harbor highly-specialized electron-dense specializations ... -
Monitoring mitochondrial translation with spatial resolution and high throughput strategies
(2023-05-30)Nearly all mitochondrial proteins are encoded in the nuclear genome, synthesized in the cytosol, and imported into mitochondria. However, mitochondria are semi-autonomous and possess their own genome, the mitochondrial DNA ... -
The Dynamic Organization of Proteins in the Synaptic Bouton
(2022-09-12)Protein availability is crucial for maintaining cellular processes. In synapses, the identities and functions of proteins involved in neurotransmission are well known. Their spatial distribution, copy numbers, and lifetimes ... -
Molecular and circuit analysis of stable contrast processing in the visual system
(2022-08-01)Visual perception gives us a reliable estimate of the world throughout the day, thanks to the computations implemented in visual circuits. In a given space or time, the relative change in luminance, contrast, forms the ... -
Targeting ion sensors to synaptic vesicles using a Nanobody against luminal Synaptotagmin 1
(2022-02-24)The synapse is a specialized nanostructure that connects two neurons where the ionic composition in each of its nano compartments is the driving process for synaptic transmission. Synaptic transmission relies on the ... -
Systematic comparison of the molecular mechanisms underlying the spreading of pathology in different neurodegenerative diseases
(2021-10-19)Misfolding and accumulation of disease-related proteins are common hallmarks among several neurodegenerative diseases. This phenomenon causes the progressive loss of cognitive and motor functions correlated with specific ... -
Unravelling the Role Cortical Myelination Plays in Higher Brain Functions
(2021-07-07)Myelination is a process within the nervous system, where axons are ensheathed by lipid-rich, multi-spiral wraps called myelin. Its main role is to expedite impulse propagation within circuitries and allow for faster ... -
Effects of arginine derivatives and oligopeptides on the physical properties of model membranes
(2021-02-16)Cell-penetrating peptides (CPPs) are often rich in arginine. They are able to cross cell membranes and carry other molecules into cells without being cytotoxic. The mechanisms by which they accomplish this are still ... -
Multicolor 3D MINFLUX nanoscopy for biological imaging
(2020-11-12)The resolution of conventional optical fluorescence far-field microscopes is limited by the diffraction of light. This implies that only features in a distance of about half of the wavelength can be discerned. In the last ... -
Studying Molecular Interactions under Flow with Fluorescence Fluctuation Spectroscopy
(2020-06-11)Assembly and interactions of biomolecules are fundamental processes in living organisms to maintain the physiological cellular behavior. The majority of the time protein assembly is useful and vital for the organism. ... -
Quantification of forces involved in carbohydrate induced attachment of carcinoma cells
(2020-02-26)Vital biological processes such as the adhesion of cells to their surroundings rely on short-term recognition processes, which are defined by a rapid assembly and disassembly of adhesion molecules. These processes were ... -
Mechanisms of regulation of mitochondria-endoplasmic reticulum contact sites
(2019-11-19)In eukaryotic cells, inter-organelle communication is crucial for several cellular functions, as well as for several cell signaling mechanisms. Mitochondria and the endoplasmic reticulum (ER), for example, form tight contact ... -
Characterization of microglial Rab7 knockout on amyloid pathology in the 5xFAD mouse model of Alzheimer’s disease
(2019-11-08)Microglia are the innate immune cells of the brain. In neurodegeneration, such as Alzheimer’s disease, these cells are involved in clearance of cellular debris and extracellular aggregates of misfolded proteins like amyloid ... -
Dissection of the molecular machinery of micro- and macronucleophagy
(2019-11-07)A highly conserved pathway required for cellular homeostasis, autophagy facilitates degradation and recycling of various cellular components. Involvement of autophagy in medical context has made associated research a highly ... -
Collective Mechanical Behavior of Epithelial Cells - The Impact of Micro-Wounding
(2019-06-24)For epithelia, which are lining organs or blood vessels, the mechanical integrity of a whole cell sheet is indispensable. The question arises, how neighboring cells mechanically work together to build a functioning cell ...