Dokumente GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach Gutachter "Ehrenreich, Hannelore Prof. Dr. Dr."
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Sleep control by TFAP2a and TFAP2b transcription factors in mice
(2023-01-31)Sleep is a universal behavior that exists across species. We previously found that deletion of transcription factor APTF-1 induces sleep loss in C. elegans and Drosophila. In mammals, sleep has two states: rapid eye movement ... -
Studies on the Involvement of the Immune system in Alzheimer's disease
(2010-08-12)The main subject of this doctoral work is the role of the immune system in Alzheimer's disease (AD), and how its understanding may help to develop novel diagnostic and therapeutic options ... -
The contribution of N-terminally modified amyloid beta to the etiology of Alzheimer's disease
(2012-09-07)A heterogeneou s mixture of amyloid beta (Aβ) isoforms exists in the brains of Alzheimer's disease (AD) patients. Despite decades of research, relatively little is known about the precise contribution of these variousAβ ... -
The EPO/EPOR system in the brain: Search for mechanisms of action
(2014-04-17)Erythropoietin (EPO) and its receptor (EPOR) are known to be essential for erythropoiesis. However, the EPO/EPOR system turned out to have additional important functions in non-hematopoietic tissue. The brain is one of the ... -
The influence of common genetic variations in candidate genes on neuropsychiatric phenotypes
(2013-08-09)Introduction: Psychiatric disorders are ‘complex diseases’. A large proportion of the phenotypic variation of psychiatric conditions like schizophrenia and autism can be attributed to additive genetic effects (80%-90%). ... -
The role of N-truncated Aβ peptides in Alzheimer’s Disease
(2018-06-29)The N-terminally truncated pyroglutamate Aβ3−42 (AβpE3−42) and Aβ4−42 peptides are known to be highly abundant in the brain of Alzheimer’s disease (AD) patients. Both peptides show enhanced aggregation and neurotoxicity ... -
Time- and gender- dependent differences in neuronal behaviors in culture
(2020-05-29)Isolating cells from a living organism and growing them in a Petri dish allowed scientists to study the physiology and biochemistry of healthy and diseased cells. Today we have cell cultures from almost any tissue type, ... -
White matter integrity of the frontal brain and its relevance for catatonia and executive function
(2021-11-22)Catatonia is a CNS derived psychomotor syndrome comprising disturbed volition and aberrant motor and behavioral features. Targeted and effective treatment today is scarce and further impeded by its heterogeneous clinical ...