Dokumente GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach Gutachter "Enderlein, Jörg Prof. Dr."
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Fullerene-Nitroxide Derivatives as Potential Polarizers for Dynamic Nuclear Polarization (DNP) in Liquid State
(2016-09-12)Nuclear magnetic resonance spectroscopy and imaging (NMR/MRI) are widely applied methods for non-destructive analysis of biological systems, materials and medical applications. Dynamic nuclear polarization (DNP) is a method ... -
Functional characterisation of RNA helicases in the remodelling of pre-ribosomal subunits
(2018-07-13)DEAD/H-box RNA helicases are ubiquitously expressed enzymes, which are characterised by a conserved helicase core of two RecA-like domains containing sequence motifs required for substrate binding and hydrolysis of NTP. ... -
Functional dynamics of the anti-HIV lectin OAA and NMR methodology for the study of protein dynamics
(2016-01-26)Specific recognition between biomolecules is at the basis of all biological processes, and a mechanistic description of molecular recognition is crucial for a detailed understanding of these processes. Two limiting models ... -
Functional photoreceptors regulating light-switchable adhesion of Chlamydomonas to surfaces
(2024-04-08)The harnessing of light is one of the most remarkable evolutionary features of microalgae, allowing them to adapt and thrive in highly dynamic environments. In order to respond to environmental changes, these photoactive ... -
Genetic determination and layout rules of visual cortical architecture
(2017-08-30)The functional architecture of the primary visual cortex is set up by neurons that preferentially respond to visual stimuli with contours of a specific orientation in visual space. In primates and placental carnivores, ... -
Illuminating the Morphological and Functional Plasticity of the Cochlear Inner Hair Cell Ribbon Synapse
(2023-10-24)Sound detection occurs in the cochlea, where sensory inner hair cells (IHC) accurately convert auditory stimuli into a neurochemical signal. Presynaptically, cochlear IHCs harbor highly-specialized electron-dense specializations ... -
Intermediate filament mechanics across scales
(2022-02-24)The mechanical properties of cells are largely determined by the cytoskeleton. The cytoskeleton is an intricate and complex structure formed by protein filaments, motor proteins, and crosslinkers. The three main types of ... -
Lipid organisation and dynamics in the myelin membrane sheets
(2014-07-25)Myelin is a unique lipid-enriched membrane, produced by oligodendrocytes in the central nervous system, that is enwrapped around axons in the multilayered fashion to ensure a swift saltatory conduction of the neuronal ... -
Microfluidic cryofixation for time-correlated live-imaging cryo-fluorescence microscopy and electron microscopy of Caenorhabditis elegans
(2018-11-01)Light and electron microscopy are complementary methods to study biological systems at the cellular and sub-cellular scale. Light microscopy is compatible with live cells, allowing features of interest to be selectively ... -
Micromechanical Mass Correlation Spectroscopy for the Characterization of Nanoparticles and Biomolecular Complexes in Fluid
(2016-03-15)Despite the wide range of techniques for the analysis of sub-micrometer objects, label- free characterization of nanoparticles in solution still remains a challenge. Microme- chanical resonators with embedded fluidic ... -
Molecular Transport in Emulsions
(2015-10-01)It is demonstrated how microfluidic tools are applied to access fundamental information on mass transfer between emulsion droplets, which are inaccessible with classical methods of bulk emulsification. Our studies were ... -
Monitoring dynamics of protein nascent chain on the ribosome using PET-FCS
(2020-06-24)The ribosome synthesizes proteins according to the sequence of the messenger RNA (mRNA) by progressively adding amino acids to the C-terminus of the nascent peptide. For a protein to become fully functional, it has to fold ... -
Multi-Directional Phase-Contrast Flow MRI in Real Time
(2021-01-28)This work describes the development of a phase-contrast MRI technique that achieves multi-directional velocity quantification in real time, i.e. at high spatio-temporal resolution and without any physiological gating or ... -
Nanoscale Brownian Dynamics of Semiflexible Biopolymers
(2020-07-24)Proteins are one of, if not the most, versatile of biology’s tools, performing a great variety of functions in living organisms and giving rise to behavior as complex as life itself. They are linear chains of amino acids ... -
Nanoscale Photonics
(2017-08-14)Detecting single nanometre scale objects and studying them in a controlled manner in solution is still a difficult task due to diffusion. We demonstrate one-dimensional nanofluidic flows of single molecules by confining ... -
Nanoscopy inside living brain slices
(2014-10-30)In order to understand how memory is processed and stored in the brain, it would be helpful to observe the ongoing memory processes in action. This is no easy task, however, if it is to be done at the synaptic level. It ... -
Nonequilibrium Statistical Mechanics
(2020-03-27)Active matter is everywhere, from macroscopic to microscopic scales, we find systems such as human crowd or flock of birds as well as bacterial colonies. These systems composed of particles are able to convert their ... -
On Control of the Excitable Dynamics in the Heart
(2019-11-19)Ventricular fibrillation, a frequent cause of death, is a heart condition associated with complex patterns of electric activity on the heart surface. In spite of a century of research many aspects of how ventricular ... -
On the mechanisms governing plasma membrane organization - a STED-FCS investigation
(2014-06-04)The plasma membrane is the barrier which localizes and separates life's processes from their external environment. Long described as a free standing two-dimensional fluid mosaic, the organization of the plasma ... -
On the Speed of Neuronal Populations
(2017-10-10)This thesis presents novel results in the areas of closed loop electrophysiology and neuronal population coding. This work begins by presenting the first known attempt to control the spike rate of a neuron or neurons using ...