Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Outeiro, Tiago Fleming Prof. Dr."
Now showing items 21-40 of 40
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Mitochondrial adaptation at the neuronal presynapse
(2021-11-22)Synaptic transmission poses a major energy consuming process in the brain, but how neurons maintain a constant energy supply during extended synaptic activity and how presynaptic mitochondria contribute to the energy ... -
Molecular insights into the Tau-actin interaction
(2018-05-04)Tau protein is classically considered as a neuronal microtubule-associated protein that stabilizes microtubules and supports the outgrowth of axons. The protein can modulate the transport of vesicles and organelles along ... -
Molecular Mechanisms of Tau Protein Aggregation Inhibition
(2013-11-11)Of all neurodegenerative diseases, Alzheimer´s Disease is the most widespread dementia syndrome, exhibiting progressive memory loss and intellectual abilities. One of the pathological hallmarks of this disease is associated ... -
N-truncated Aβ4-x peptides in Alzheimer's disease: generation, degradation, and relationship with neuropathological hallmarks
(2021-12-20)Amyloid pathology in Alzheimer’s disease (AD) is characterized by a heterogeneity of amyloid-β peptides (Aβ) variants. The N-terminally truncated Aβ4-42 peptides are among the most abundant species and were reported having ... -
Neurotoxicity and aggregation of β-synuclein and its P123H and V70M mutants associated with dementia with Lewy bodies
(2019-06-14)Dementia with Lewy bodies is a progressive degenerative brain disorder which accounts for 7 to 25% of all dementia cases. Two rare missense mutations of β-synuclein, P123H and V70M were identified in familial and sporadic ... -
Novel Applications of Super-Resolution Microscopy in Molecular Biology and Medical Diagnostics
(2016-03-31)Despite recent advances in microscopy techniques, the underlying labeling assays remained mostly unchanged. However, super-resolution techniques require other staining conditions than conventional light microscopy, like ... -
Onset and Progression of Neurodegeneration in Mouse Models for Defective Endocytosis
(2019-10-25)Neurodegenerative diseases have become an increasing problem in our aging society. Many studies have addressed these complex diseases in the recent years. Scientists have learned a lot about specific proteins, their ... -
Organelle dysfunction modulates cholesterol biosynthesis pathway
(2019-10-01)Mitochondria are known as the powerhouse of the cells. However, in recent years, it has become increasingly evident that mitochondria are involved in several signaling pathways. Lysosomes are membrane-bound organelles that ... -
Pathophysiological effects of Beta-Synuclein mutants P123H and V70M
(2023-07-24)Mutations in the beta-synuclein protein have been directly linked to Dementia with Lewy bodies (DLB). In particular, P123H mutation was linked to a familial case of DLB, whereas V70M mutation was identified in a sporadic ... -
Resolving Dopamine Secretion at Individual Varicosities using Carbon Nanotube-Based Optical Dopamine Nanosensors
(2021-07-23)Dopamine (DA) is a neurotransmitter that controls vital brain functions such as motor control and motivation, but little is known about the molecular mechanisms that control DA release. Neurotransmission through DA differs ... -
Structural insight of MODAG-005 on 𝛼-Synuclein aggregates as a novel PET tracer
(2024-11-15)Neurodegenerative disorders, including Parkinson's disease (PD) and related synucleinopathies, are characterized by the accumulation of pathological protein aggregates in the brain. Among the key proteins implicated in ... -
Targeting ion sensors to synaptic vesicles using a Nanobody against luminal Synaptotagmin 1
(2022-02-24)The synapse is a specialized nanostructure that connects two neurons where the ionic composition in each of its nano compartments is the driving process for synaptic transmission. Synaptic transmission relies on the ... -
Targeting microglial CSF1R in health and disease
(2021-09-03)The main effector functions of microglia are immune, synaptic network refinement, brain insult reaction, and neurogenesis regulation. This cumulative doctoral thesis focuses on the relevance of the colony-stimulating factor ... -
The influence of epigenetic alterations on synaptic function and memory
(2022-08-24)While memory formation is traditionally linked to changes in synaptic structure, the transcriptional processes enabling these changes are often understudied. Even though novel protein synthesis is the basis of long-term ... -
The interplay between α-synuclein and Rab GTPases: Insights into the molecular basis of synucleinopathies
(2015-03-24)Ageing related diseases become of ever more significance with the demographic shift currently prevalent in society. Dementia and movement disorders impact individuals and families alike, as the progressive decline in ... -
The role of N-truncated Aβ peptides in Alzheimer’s Disease
(2018-06-29)The N-terminally truncated pyroglutamate Aβ3−42 (AβpE3−42) and Aβ4−42 peptides are known to be highly abundant in the brain of Alzheimer’s disease (AD) patients. Both peptides show enhanced aggregation and neurotoxicity ... -
The role of RNA in synaptic physiology and neurodegeneration in synucleinopathies
(2025-01-23)Synucleinopathies are neurodegenerative disorders characterised by the pathological accumulation and aggregation of the protein alpha-synuclein (aSyn). Parkinson’s disease (PD), Dementia with Lewy bodies (DLB), multiple ... -
The role of the E3 ubiquitin ligase FBXO7-SCF in early-onset Parkinson's disease
(2016-08-29)Parkinson's disease (PD) is a debilitating movement disorder. Growing evidence associates genes with familial forms of the disease. Recently, gene mutations in the FBXO7 (PARK15) gene have been identified in patients with ... -
The Synaptic RNAome - identification, interactions and intercellular transfer
(2021-03-19)Synaptic plasticity is how neurons adapt to new stimuli and necessitates changes in synaptic weight. For these changes to be durable, local translation in neurites, and at pre- and post-synapses is required. Current methods ... -
White matter integrity of the frontal brain and its relevance for catatonia and executive function
(2021-11-22)Catatonia is a CNS derived psychomotor syndrome comprising disturbed volition and aberrant motor and behavioral features. Targeted and effective treatment today is scarce and further impeded by its heterogeneous clinical ...