Dokumente GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach Gutachter "Wienands, Jürgen Prof. Dr."
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Role of antibodies in autoimmunity of the central nervous system
(2020-07-09)Although T cells are the main players in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE), the role of B cells and their soluble effector molecules (antibodies) is being progressively ... -
Structural and functional elucidation of the primary transducer module of the B cell antigen receptor
(2015-07-27)Interaction of an antigen with the B cell antigen receptor (BCR) initiates signaling cascades leading to B cell activation, proliferation and differentiation. Signal transduction downstream of the BCR depends on the adaptor ... -
Das synaptische Vesikelrecycling: Molekulare Funktionen des AP-1-Komplexes und seiner σ1B-Adaptinuntereinheit
(2012-09-26)The heterotetrameric AP-1-complex is localized to trans-Golgi-Network (TGN) and early endosomes. It mediates specific clathrin-dependant vesicular pathways. In vertebrates three isoforms of its σ1 subunit are expressed: ... -
The membrane IgE tail imparts unique signaling properties to the B cell antigen receptor
(2017-10-23)Robust memory antibody responses are a distinguishing feature of humoral immunity and are typically marked by elevated serum immunoglobulin (Ig) titers that rapidly and effectively neutralize the invading pathogen. However, ... -
The role of microRNAs in the p53 tumor suppressor pathway
(2011-12-16)MicroRNAs (miRNAs) are a class of small, non-coding, double-stranded RNA molecules. In metazoan cells, miRNAs recognize their target mRNAs by imperfectly complementary binding, leading to ... -
Unraveling details of CIN85/CD2AP assistance to SLP65-mediated B cell activation
(2020-06-18)The hallmark of adaptive immunity is the production of specific antibodies. This process is initiated upon the ligation of the B cell antigen receptor (BCR) which activates multiple intracellular signaling cascades through ... -
Vav guanine nucleotide exchange factors control B cell antigen receptor-induced Ca2+-signaling
(2016-03-15)Differentiation of B cells into antibody secreting plasma cells is an indispensable step to cope with pathogens. Antigen binding to the B cell antigen receptor (BCR) initiates signaling cascades leading in combination with ...