Dokumente GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach Gutachter "Wimmer, Ernst A. Prof. Dr."
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The role of <i>Satb2</i>, <i>Ctip2</i> and Fezl in cortical connectivity and the elucidation of their downstream pathways
(2012-06-06)Satb2 has been shown to be a key postmitotic determinant of callosal projection neurons (Alcamo et al., 2008; Britanova et al., 2008). One way by which Satb2 is acting to confer such identity involves the repression of Ctip2, ... -
The Role of alpha- and beta-SNAP in Synaptic Vesicle Exocytosis
(2008-08-04)Neurotransmitter release is mediated by the neuronal SNARE proteins, which are transmembrane proteins whose assembly into ternary complexes is thought to drive membrane fusion of synaptic ... -
The role of the FACT complex in differentiation of multipotent stem cells
(2017-04-27)Cellular differentiation is accompanied by dramatic changes in chromatin structure which are associated with the activation of lineage-specific transcriptional programs. Facilitates Chromatin Transcription (FACT) is a ... -
The secreted serine protease xHtrA1 is a positive feedback regulator of long-range FGF signaling.
(2007-09-13)Fibroblast growth factors (FGFs) are important signaling molecules, whose activities need to be tightly controlled. We have recently identified the Xenopus homolog of HtrA1 (xHtrA1) in a ... -
Thermosensory Transduction Mechanisms in Drosophila melanogaster
(2019-10-18)Ambient temperature has an profound effect in the physiology of all animals and accurate evaluation of both external and internal temperatures is therefore an essential factor for fitness and survival. To this end, animals ... -
Understanding Nucleosome Assembly Regulation in Drosophila melanogaster
(2022-06-24)Nucleosomes consist of a complex of DNA and an octameric core of histone proteins, which represent the basic subunit of chromatin. The N-terminal tails of histones are target for chemical modifications, which play an ... -
Zebrafish as a Model for Hereditary Spastic Paraplegia
(2023-06-28)To investigate the mechanism of pathogenesis of the rare and complex neurodegenerative disorder Hereditary Spastic Paraplegia (HSP), which causes lower limb motility defects, it is crucial to establish simple and tractable ...