Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Advisor & Referee "Göpfert, Martin Prof. Dr."
Now showing items 21-37 of 37
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Mechanical Properties of the lch5 Organ in the Drosophila Larva
(2017-09-08)I begin with a brief account of the topic of mechanosensation, followed by an outline of how the project evolved. The experimental techniques used and their rationale are described. The section ends with a short description ... -
Analyzing receptor responses in the Drosophila Johnston's organ with two-photon microscopy
(2017-07-31)Hearing organs rely on force-gated ion channels to convert the mechanical energy imposed by sound into receptor potentials usable by the nervous system. So far, little is known about the identity and working mechanisms of ... -
Molecular studies of the synaptic protein otoferlin
(2017-02-24)Deafness is an interesting and intensely studied topic and can be caused by different, genetic as well as environmental, factors. One important cause of deafness are mutations in the otoferlin gene leading to non-syndromic ... -
Developmental Studies of Appendage Patterning and Formation in Spiders
(2016-11-21)In the animal kingdom arthropods are unparalleled in species number and diversity. Especially their appendages show a great morphological diversity and are adapted for different purposes like feeding, walking, flying, ... -
Identification of the molecular changes underlying head morphology variation in closely related Drosophila species
(2016-09-09)The great diversity of adult morphologies that we can observe in nature is the product of millions of years of evolution of the underlying developmental programs. The genes that code for the transcription factors and ... -
Probing roles of TRPML in Drosophila hearing
(2016-01-15)Several transient receptor potential (TRP) channels have been implicated in Drosophila hearing, including the TRPN channel NOMPC, the TRPVs Nan and Iav, and the TRPA members Pyx and Pain. Here I report that fly hearing ... -
Cellular mechanisms of odor detection in the olfactory system of the red flour beetle Tribolium castaneum
(2015-10-26)Olfaction, the detection of odors is pivotal for insects, since it leads them to food sources or mating partners and triggers important behaviors. For the detection of pheromones, CD36-related sensory neuron membrane ... -
Neuronal Circuit Dissection in the Drosophila Brain: the Role of Serotonin-Releasing Neurons in Arousal
(2014-08-18)For animals, an optimal arousal state is essential for motivating or inhibiting a specific behavior. Arousal is regarded to be an internal factor that influences the initiation and execution of different behaviors, and is ... -
Axonemal dyneins and force generation by neurons in Drosophila melanogaster ear
(2014-05-26)Analogous to vertebrate hair cells, the mechanosensory cilia of Drosophila auditory neurons are motile and serve dual, transducing and actuating roles. Structurally, the latter cilia resemble non-motile primary cilia, ... -
Sound Encoding in the Mouse Cochlea: Molecular Physiology and Optogenetic Stimulation
(2014-04-24)Afferent synapses between inner hair cells (IHCs) and spiral ganglion neurons in the cochlea translate sound information into a discrete spike code, providing us the opportunity to directly observe the output of the cochlea. ... -
Biophysical modeling of information processing in the <i>Drosophila</i> olfactory system
(2014-04-24)Fruit flies (Drosophila melanogaster) rely on their olfactory system to process environmental information. Although extensive studies have helped neurobiologists to understand the basic molecular and cellular mechanisms ... -
Synaptic physiology of the cochlear sound encoding
(2013-11-27)Sound intensity is encoded as action potential firing rates by spiral ganglion neurons. These neurons show different rate-level functions with different auditory thresholds, and are thought to collectively encode the large ... -
Gene Ontology-based framework to annotate genes of hearing
(2013-10-22)As the number of discovered deafness genes and our knowledge about their role in hearing continuously increases, the need to accurately manage this genetic information is becoming more apparent. Gene Ontology (GO) is a ... -
Genetics of Drosophila hearing
(2013-10-04)By probing Johnston’s organ function in mutant fly strains, mutations in forty-four genes that affect Drosophila hearing have been identified. This result increases the list of genes that are known for audition by 180 % ... -
Expression and function of Rab3 interacting molecules and clarin-1 in inner hair cells
(2013-09-04)Hearing depends on faithful synaptic transmission at the inner hair cell (IHC) ribbon synapse, which is orchestrated by active zone proteins. RIM (Rab3 Interacting Molecules) is one of the active zone proteins and proposed ... -
A Functional Characterisation of Drosophila Chordotonal Organs
(2013-06-27)Functional properties of the Drosophila FCO (femoral chordotonal organ) can be dissected by use of the Gal4-UAS system in combination with transcuticular in vivo Calcium imaging. As sinusoidal stimulation at relative ... -
Synaptic Ultrastructure and Regulation of Synaptic Transmission in Caenorhabditis elegans
(2012-11-07)The triggered release of synaptic vesicles (SVs) is tightly regulated in time and space by an elaborate network of proteins forming the active zone (AZ). When visualized by electron microscopy (EM), a morphological hallmark ...