Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Advisor & Referee "Zweckstetter, Markus Prof. Dr."
Now showing items 21-27 of 27
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Residue level characterization of molecular interactions of intermembrane space domains governing the preprotein import into the mitochondrial matrix
(2014-12-10)Mitochondrial matrix targeting proteins are translated as preproteins (carrying an N-terminal 20-50 residue presequence) in the cytoplasm. Post-translationally, they are imported into the mitochondrial matrix through ... -
Crystal Structure and Characterization of the SCOC Coiled Coil Domain
(2014-08-06)Autophagy is a conserved eukaryotic process for the degradation of cytosolic content. An expanding double layered membrane takes up part of the cytoplasm and matures to an autophagosomal vesicle. The autophagosome ... -
Solution NMR-based characterization of the structure of the outer mitochondrial membrane protein Tom40 and a novel method for NMR resonance assignment of large intrinsically disordered proteins
(2014-05-08)This dissertation is composed of two parts. In the first part, the characterization of the structure of liposome-embedded Tom40 using a novel hydrogen/deuterium (H/D) exchange method is described. In the second part, a new ... -
Structural insights into Arginine-Serine rich proteins and N-H spin-spin coupling constants
(2013-11-27)This thesis is constituted of two parts. In the first part of this thesis, I studied the structural phenomena of SR protein phosphorylation. The serine/arginine-rich (SR) protein family plays multiple functions in the whole ... -
Mechanistic insights into alpha-Synuclein neuronal toxicity: misfolding, serine phosphorylation and interactions with Rab GTPases
(2013-11-18)Alpha-Synuclein(aS), a protein abundant in presynaptic neurons, has been found as the major component of Lewy bodies, the neuronal inclusion identified as the hallmark of Parkinson’s disease (PD). aS adopts intrinsically ... -
Molecular Mechanisms of Tau Protein Aggregation Inhibition
(2013-11-11)Of all neurodegenerative diseases, Alzheimer´s Disease is the most widespread dementia syndrome, exhibiting progressive memory loss and intellectual abilities. One of the pathological hallmarks of this disease is associated ... -
The identification and characterization of Mio10 and MINOS1 as novel regulators of mitochondrial inner membrane organization
(2012-06-07)Various mitochondrial inner membrane proteins contribute to the structure of cristae membranes and to the overall dynamic morphology of the inner membrane. These proteins include the F1FOATPase dimers, which contribute to ...