Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Dresbach, Thomas Prof. Dr."
Now showing items 21-30 of 30
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Molecular physiology of synaptic sound encoding at the first auditory synapse
(2018-03-20)To achieve accurate encoding of sounds, inner hair cell (IHC) ribbon-type synapses are highly specialized to release synaptic vesicles (SVs) with high rates and temporal precision. A sophisticated, by far not yet fully ... -
Activity-based automatic ROI generation (AARG) analysis of dendritic spine calcium transients reveals distance-dependent activity of voltage-gated calcium channels
(2018-03-20)Imaging synaptic activity in the form of calcium transients occurring in dendritic spines is advancing our understanding of nerve cell function beyond what can be achieved using electrophysiological methods alone. I have ... -
Investigation of Vesicle Pool Dynamics at Activity Modulated Inner Hair Cell Ribbon Synapses
(2018-01-18)The inner hair cell ribbon synapses are the relay stations of the auditory pathway, attuned to transmit acoustic information at rates of up to hundreds of Hz. Such indefatigable signal transmission demands ultrafast vesicle ... -
Molecular physiology of signal transmission along the auditory pathway
(2017-12-13)Signal transmission lies at the core of brain function. Understanding how information is transferred from one neuron to the other is the first step toward deciphering not just normal brain processing but the pathology of ... -
Ultrastructural Characterization of The Output of VIP Expressing Interneurons in Mouse Barrel Cortex
(2017-11-15)Based on this preliminary result, a quantitative immunoelectron microscopy study was adopted to comprehensively characterize the output of VIP interneurons across the whole laminae of mouse barrel cortex. Using VIPcre/YFP ... -
Electrophysiological Analysis of the Synaptic Vesicle Priming Process
(2017-08-17)Chemical synaptic transmission is the most prominent communication channel employed by neural circuits. It is initiated by the action potential triggered fusion of transmitter-filled synaptic vesicles with the presynaptic ... -
Characterization of FBXO7 (PARK15) knockout mice modeling Parkinsonian-Pyramidal Syndrome
(2017-04-19)The second most common neurodegenerative disease, Parkinson’s disease (PD), is caused by loss of dopaminergic neurons in the substantia nigra leading to impaired motor control. Genetic analyses have revealed recessively ... -
Molecular studies of the synaptic protein otoferlin
(2017-02-24)Deafness is an interesting and intensely studied topic and can be caused by different, genetic as well as environmental, factors. One important cause of deafness are mutations in the otoferlin gene leading to non-syndromic ... -
The role of Calcium Binding Protein 2 in synaptic sound encoding and hearing
(2016-11-29)Hearing is a unique sensory feature providing the individual with acoustic information about the surrounding environment. Humans rely on hearing to localize potential dangers and it is essential for communication and social ... -
Synergistic SNARE Modulators of Neurotransmission: Complexins and SNAP-29
(2016-05-04)Neurotransmitter release is a synergistic multistep process occurring at synapses in the brain. Synaptic vesicles containing neurotransmitters tether to the presynaptic active zones, upon which, they are docked and primed ...