Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Enderlein, Jörg Prof. Dr."
Now showing items 21-40 of 66
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Reverse-time inference of biological dynamics
(2020-10-27)In this work I derive a mathematical theory that allows to infer directional biological dynamics in reverse time starting from their target state. I use this approach to infer an effective model of cell junction shrinkage ... -
Nanoscale Brownian Dynamics of Semiflexible Biopolymers
(2020-07-24)Proteins are one of, if not the most, versatile of biology’s tools, performing a great variety of functions in living organisms and giving rise to behavior as complex as life itself. They are linear chains of amino acids ... -
Monitoring dynamics of protein nascent chain on the ribosome using PET-FCS
(2020-06-24)The ribosome synthesizes proteins according to the sequence of the messenger RNA (mRNA) by progressively adding amino acids to the C-terminus of the nascent peptide. For a protein to become fully functional, it has to fold ... -
The roles of RNA helicases and other ribosome biogenesis factors during small subunit maturation
(2020-05-29)RNA helicases are a highly conserved family of proteins that act as RNA-dependent NTPases. These proteins contain a conserved helicase core consisting of two RecA-like domains that are responsible for unwinding or annealing ... -
Perturbation of Pattern Formation in Dictyostelium Discoideum via Flow and Spatial Heterogeneities
(2020-04-07)In this thesis, we investigate the signalling process of the social amoeba Dictyostelium discoideum (D. discoideum) as a model reaction-diffusion-advection system. Colonies of these cells are an excitable medium that ... -
Nonequilibrium Statistical Mechanics
(2020-03-27)Active matter is everywhere, from macroscopic to microscopic scales, we find systems such as human crowd or flock of birds as well as bacterial colonies. These systems composed of particles are able to convert their ... -
The Viscoelastic Response of Liquid Crystalline Fibers Formed By Bent-core Molecules
(2019-11-20)A free-standing fluid fiber must suppress the radial fluctuations described by the Rayleigh- Plateau (R-P) instability. The stability of such structures are typically restricted to polymers or naturally-occurring spider ... -
On Control of the Excitable Dynamics in the Heart
(2019-11-19)Ventricular fibrillation, a frequent cause of death, is a heart condition associated with complex patterns of electric activity on the heart surface. In spite of a century of research many aspects of how ventricular ... -
Optimization and application of Trim-Away for studying a liquid-like spindle domain in mammalian oocytes
(2019-10-01)In this thesis, I reported a membraneless structure that permeated a major region of the female meiotic spindle and formed droplet-like protrusions around the spindle poles. Proteins within this previously unknown structure ... -
Extending Resolution in All Directions: Image Scanning Microscopy and Metal-induced Energy Transfer
(2019-03-18)Fluorescence microscopy is a powerful tool in the life sciences and is used to study structure and function on length scales from cells down to single molecules. In recent years, fluorescence microscopy has seen enormous ... -
The Principles of Self-Organization of Memories in Neural Networks for Generating and Performing Cognitive Strategies
(2018-12-12)Higher-order animals exhibit the remarkable ability to dynamically adapt to a changing environment. On the neuronal level, they have to form mental representations of specific stimuli, so-called memories. Furthermore, ... -
Microfluidic cryofixation for time-correlated live-imaging cryo-fluorescence microscopy and electron microscopy of Caenorhabditis elegans
(2018-11-01)Light and electron microscopy are complementary methods to study biological systems at the cellular and sub-cellular scale. Light microscopy is compatible with live cells, allowing features of interest to be selectively ... -
Optical bionanosensors for neurotransmitter detection
(2018-10-17)Information transfer in the human brain is enabled by neurotransmitters - messenger molecules that diffuse between cells. Static concentration measurements are useful to identify molecules involved in neurotransmission, ... -
Active and Passive Microrheology of F-Actin Membrane Composites
(2018-07-19)The complex mechanical properties of a living cell are not only a function of its structural components but also of the organizational super-structure and the dynamic interconnection of filaments, proteins and the plasma ... -
Functional characterisation of RNA helicases in the remodelling of pre-ribosomal subunits
(2018-07-13)DEAD/H-box RNA helicases are ubiquitously expressed enzymes, which are characterised by a conserved helicase core of two RecA-like domains containing sequence motifs required for substrate binding and hydrolysis of NTP. ... -
Chaotic Neural Circuit Dynamics
(2018-02-09)Information is processed in the brain by the coordinated activity of large neural circuits. Yet, we are still only starting to understand how this high-dimensional complex system gives rise to functions such as processing ... -
On the Speed of Neuronal Populations
(2017-10-10)This thesis presents novel results in the areas of closed loop electrophysiology and neuronal population coding. This work begins by presenting the first known attempt to control the spike rate of a neuron or neurons using ... -
Genetic determination and layout rules of visual cortical architecture
(2017-08-30)The functional architecture of the primary visual cortex is set up by neurons that preferentially respond to visual stimuli with contours of a specific orientation in visual space. In primates and placental carnivores, ... -
Nanoscale Photonics
(2017-08-14)Detecting single nanometre scale objects and studying them in a controlled manner in solution is still a difficult task due to diffusion. We demonstrate one-dimensional nanofluidic flows of single molecules by confining ... -
Probing Molecular Stoichiometry by Photon Antibunching and Nanofluidics Assisted Imaging in Solution
(2017-07-05)A mechanistic understanding of biological function requires a quantitative determination of macromolecular subunit architecture and interaction. Optical microscopy and spectroscopy provide a noninvasive method to characterize ...