Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Heinrich, Ralf Prof. Dr."
Now showing items 21-36 of 36
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Peripheral nervous system control for neuroprostheses
(2017-09-21)Amputee patients who have lost a hand or arm are severely impaired in their daily life, as they lose the ability to grasp and interact with their environment. While the use of electromyographically controlled prosthetic ... -
Characterization of FBXO7 (PARK15) knockout mice modeling Parkinsonian-Pyramidal Syndrome
(2017-04-19)The second most common neurodegenerative disease, Parkinson’s disease (PD), is caused by loss of dopaminergic neurons in the substantia nigra leading to impaired motor control. Genetic analyses have revealed recessively ... -
Untangling neuronal diversity: a quantitative electrophysiological and morphological characterization of VIP expressing interneurons
(2017-03-21)VIP expressing interneurons are an essential component of cortical circuitry. This distinct subgroup of inhibitory interneurons was always described as the most heterogeneous subgroup of inhibitory interneurons. However, ... -
From hearing to singing:sensory to motor information processing in the grasshopper brain
(2016-08-02)Grasshoppers, and among them especially the species Chorthippus biguttulus, have been used as a model system to study the neuronal basis of acoustic behavior. Auditory neurons have been described from intracellular recordings. ... -
Probing roles of TRPML in Drosophila hearing
(2016-01-15)Several transient receptor potential (TRP) channels have been implicated in Drosophila hearing, including the TRPN channel NOMPC, the TRPVs Nan and Iav, and the TRPA members Pyx and Pain. Here I report that fly hearing ... -
AAV-based gene therapy for axonal regeneration in a rat model of rubrospinal tract lesion
(2015-04-29)Spinal cord injury (SCI) is a devastating and largely irreversible clinical condition, which can lead to permanent sensory and motor functional disabilities. Worldwide, an estimated 2.5 million people suffer from SCI and ... -
GABA and glycine co-transmission in the developing mouse respiratory network
(2014-11-18)Inhibitory neurons in the pre-Bötzinger complex - a kernel for respiratory rhythm generation, are involved in the respiratory rhythm modulation. The co-transmission of GABA and glycine has been reported in different brain ... -
Characterization of the CNS-specific F-box protein FBXO41 in cerebellar development
(2014-05-28)During neurodevelopment, processes like neurogenesis, neuronal migration and morphogenesis, as well as synaptogenesis determine the shape and function of the brain. All developmental events are highly coordinated by extrinsic ... -
Effects of stress on the GABAergic system in the hippocampal formation and medial prefrontal cortex of the adult male rat
(2011-04-21)Stress facilitates the development of psychiatric disorders in vulnerable individuals. Previous studies have well documented the impact of stress on glutamatergic excitatory transmission ... -
Characterization of olfactory receptor gene expression in the olfactory epithelium of larval Xenopus laevis
(2011-02-09)Olfactory receptors comprise the largest multigene family of G protein-coupled receptors in organisms ranging from fish to primates and are the detectors of thousands of odorant molecules. ... -
Identification and Analysis of Gene Product Modifiers of α-Synuclein Toxicity in the Fruit Fly (D. Melanogaster).
(2010-09-22)Parkinson s disease (PD) is a progressive neurodegenerative disorder, pathologically characterized by loss of dopaminergic neurons in the substantia nigra pars compacta. Various mutations ... -
Mechanisms of Neuroligin Function in Inhibitory Postsynaptic Differentiation
(2009-10-14)The establishment of accurate synaptic transmission underlies neural network processing and nervous system function. The organized deployment of specialized synaptic machinery is a key ... -
Molecular mechanisms of the effect of the mood stabilizer lithium on cAMP-induced CREB transcriptional activity
(2009-07-03)Lithium salts are used now for 60 years to treat bipolar disorder, a chronic, severe and often life-threatening illness characterized by recurrent phases of the two opposing mood states of ... -
Neue Behandlungsansätze für neuropsychiatrische Erkrankungen basierend auf der Identifizierung molekularer Krankheitsdeterminanten
(2009-04-21)Major neuropsychiatric diseases, including schizophrenia and bipolar disorder, deteriorate higher brain functions leading to disorganized thinking and cognitive decline. Available treatments ... -
Signalling of hematopoietic growth factors in mammalian neural cells
(2007-07-31)This dissertation examines signalling of hematopoietic growth factors in hippocampal neurons and cortical astrocytes. The activity patterns of Akt, ERK1/2 and Stat3 after treatment with ... -
Hemisphere and region - specific effects of chronic stress in the rat prefrontal cortex
(2007-05-03)This thesis demonstrated that pyramidal neurons of the prelimbic and infralimbic area of the rat prefrontal cortex had an intrinsic morphological asymmetry in that pyramidal neurons in the ...