Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Nave, Klaus-Armin Prof. Dr."
Now showing items 21-32 of 32
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Assessment of Epigenetic profile in Alzheimer's disease
(2012-11-30)Alzheimer's disease is caused by multivariate factors with a convergent insult to neuronal integrity leading to cognitive decline and neurodegeneration. To develop an efficient therapeutic strategy for treatment of AD calls ... -
Pathways for phospholipid deacylation in Saccharomyces cerevisiae and their impact on fatty acid trafficking and equilibrium
(2011-01-25)The phospholipid (PL) class and species composition is a fundamental characteristic of membranes, essential to their proper function. The PL species distribution of cellular lipids is only ... -
Investigation of Sip1 gene interactions in the development of the mammalian telencephalon
(2010-08-02)The transcriptional repressor Sip1, or Smad- interacting protein 1, has been shown to play a key role in early neurodevelopment. Mowat- Wilson Syndrome in humans is associated with mutations ... -
BACE1 dependent function of Neuregulin1 in peripheral nervous system myelination
(2010-05-26)The neuronal epidermal growth factor (EGF)-like growth factor NRG1 type III serves as a master regulator of myelination in the peripheral nervous system (PNS). It has been proposed that ... -
The Role of Phosphoinositides in the Interaction of Myelin Basic Protein with the Oligodendroglial Cell Membrane
(2010-02-09)The only protein known to be essential for myelin formation and compaction in the central nervous system is myelin basic protein (MBP). Oligodendrocytes in mutant mice that lack MBP-expression ... -
Combining induced protease fragment assembly and microarray analysis to monitor signaling in living cells.
(2009-11-19)The ability to monitor multiple signaling events simultaneously in living cells is essential to better understand complex biological processes. So far, DNA-microarray technologies provide ... -
Molecular mechanisms of the effect of the mood stabilizer lithium on cAMP-induced CREB transcriptional activity
(2009-07-03)Lithium salts are used now for 60 years to treat bipolar disorder, a chronic, severe and often life-threatening illness characterized by recurrent phases of the two opposing mood states of ... -
"Eine neue Rolle für Myelin-assoziierte Inhibitoren für die Mobilität von Mikroglia"
(2009-05-28)In the central nervous system of mammals, the regeneration of axons after injury is limited. The reduced ability of neurite outgrowth can be attributed, in part, to the presence of inhibitor proteins enriched in myelin. ... -
Neue Behandlungsansätze für neuropsychiatrische Erkrankungen basierend auf der Identifizierung molekularer Krankheitsdeterminanten
(2009-04-21)Major neuropsychiatric diseases, including schizophrenia and bipolar disorder, deteriorate higher brain functions leading to disorganized thinking and cognitive decline. Available treatments ... -
Huntingtin toxicity is ameliorated by BAG1 through modulation of its aggregation, degradation and subcellular distribution
(2009-02-23)Huntington s disease (HD) is a fatal neurodegenerative disorder resulting from an expansion of a polyglutamine stretch in a ubiquitously expressed protein called huntingtin. Intraneuronal ... -
The role of bHLH transcription factor NEX in neuronal differentiation and experience-dependent plasticity
(2008-02-12)NEX (neuronal helix-loop-helix protein) is an atonal-related basic helix-loop-helix (bHLH) transcription factor that belongs to the subfamily of neuronal differentiation factors, which also includes NeuroD and NDRF. NEX ... -
Grey matter pathology in multiple sclerosis
(2006-01-30)Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. MS has traditionally been considered a disease affecting the well myelinated white matter ...