Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Outeiro, Tiago Fleming Prof. Dr."
Now showing items 21-40 of 40
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Alpha-synuclein spreading pathology in Parkinson's disease: the influence of iron and the Rho-kinase inhibitor fasudil
(2020-06-05)Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease affecting approximately 1 % of the population above 60 years of age. It affects preferentially the extrapyramidal system, causing severe ... -
Onset and Progression of Neurodegeneration in Mouse Models for Defective Endocytosis
(2019-10-25)Neurodegenerative diseases have become an increasing problem in our aging society. Many studies have addressed these complex diseases in the recent years. Scientists have learned a lot about specific proteins, their ... -
Organelle dysfunction modulates cholesterol biosynthesis pathway
(2019-10-01)Mitochondria are known as the powerhouse of the cells. However, in recent years, it has become increasingly evident that mitochondria are involved in several signaling pathways. Lysosomes are membrane-bound organelles that ... -
Microglia activation and regulation of remyelination in the central nervous system
(2019-08-21)In the central nervous system, remyelination requires the proliferation and migration of oligodendrocyte progenitor cells (OPCs) to the lesions, and the differentiation of OPCs into oligodendrocytes that remyelinate the ... -
Functional Analysis of E3 Ubiquitin Ligases in Developing Neurons
(2019-08-15)Neuronal development starts after the closure of the neural tube when neural stem cells begin to divide asymmetrically at the ventricular zone of the forebrain. Newborn neurons then migrate vertically from the ventricular ... -
Neurotoxicity and aggregation of β-synuclein and its P123H and V70M mutants associated with dementia with Lewy bodies
(2019-06-14)Dementia with Lewy bodies is a progressive degenerative brain disorder which accounts for 7 to 25% of all dementia cases. Two rare missense mutations of β-synuclein, P123H and V70M were identified in familial and sporadic ... -
Decoding the Epigenome of Neuronal Networks in Health and Disease
(2019-05-27)Alzheimer’s disease (AD) is the most prevalent form of dementia that has vast emotional and economic implications in our society. There is no cure for this neurodegenerative disorder as the pathological changes occur years ... -
Changes in gene expression linked to Alzheimer's disease and "healthy" cognitive aging
(2019-02-20)Alzheimer’s disease (AD) is a neurodegenerative disease and the most common form of dementia. The number of AD cases increases exponentially every year. Although AD has been investigated for a long time, the precise ... -
The role of N-truncated Aβ peptides in Alzheimer’s Disease
(2018-06-29)The N-terminally truncated pyroglutamate Aβ3−42 (AβpE3−42) and Aβ4−42 peptides are known to be highly abundant in the brain of Alzheimer’s disease (AD) patients. Both peptides show enhanced aggregation and neurotoxicity ... -
Molecular insights into the Tau-actin interaction
(2018-05-04)Tau protein is classically considered as a neuronal microtubule-associated protein that stabilizes microtubules and supports the outgrowth of axons. The protein can modulate the transport of vesicles and organelles along ... -
Functional analysis of the parkinsonism-associated protein FBXO7 (PARK15) in neurons
(2017-09-07)Parkinson's disease (PD) is a debilitating neurodegenerative disease affecting the elderly population. It has been a challenge elucidating the molecular mechanisms underlying the selective loss of dopaminergic neurons, ... -
Alpha-synuclein aggregation: visualization by X-ray techniques and its modulation by iron
(2017-09-06)Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide. It’s a progressive disease that can be treated only symptomatically and its causes are still not fully understood. Two main factors ... -
Characterization of FBXO7 (PARK15) knockout mice modeling Parkinsonian-Pyramidal Syndrome
(2017-04-19)The second most common neurodegenerative disease, Parkinson’s disease (PD), is caused by loss of dopaminergic neurons in the substantia nigra leading to impaired motor control. Genetic analyses have revealed recessively ... -
The role of the E3 ubiquitin ligase FBXO7-SCF in early-onset Parkinson's disease
(2016-08-29)Parkinson's disease (PD) is a debilitating movement disorder. Growing evidence associates genes with familial forms of the disease. Recently, gene mutations in the FBXO7 (PARK15) gene have been identified in patients with ... -
Novel Applications of Super-Resolution Microscopy in Molecular Biology and Medical Diagnostics
(2016-03-31)Despite recent advances in microscopy techniques, the underlying labeling assays remained mostly unchanged. However, super-resolution techniques require other staining conditions than conventional light microscopy, like ... -
Actin turnover regulates mechanical properties of oligodendrocytes and myelin formation
(2015-10-02)The myelin sheath is a specialized membranous structure that facilitates rapid signal conduction along axonal segments. During central nervous system development, it is formed by oligodendrocytes that extend motile and ... -
In Vitro and In Vivo Studies on Antibodies - N-terminally Truncated Abeta in the 5XFAD Mouse Model
(2015-05-29)Commonly used transgenic mouse models mimic Alzheimer´s disease (AD) to some extent but do as well display differences compared to the human AD phenotype. Growing evidence indicates that N-terminally truncated isoforms, ... -
AAV-based gene therapy for axonal regeneration in a rat model of rubrospinal tract lesion
(2015-04-29)Spinal cord injury (SCI) is a devastating and largely irreversible clinical condition, which can lead to permanent sensory and motor functional disabilities. Worldwide, an estimated 2.5 million people suffer from SCI and ... -
The interplay between α-synuclein and Rab GTPases: Insights into the molecular basis of synucleinopathies
(2015-03-24)Ageing related diseases become of ever more significance with the demographic shift currently prevalent in society. Dementia and movement disorders impact individuals and families alike, as the progressive decline in ... -
Molecular Mechanisms of Tau Protein Aggregation Inhibition
(2013-11-11)Of all neurodegenerative diseases, Alzheimer´s Disease is the most widespread dementia syndrome, exhibiting progressive memory loss and intellectual abilities. One of the pathological hallmarks of this disease is associated ...