Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Rehling, Peter Prof. Dr."
Now showing items 21-38 of 38
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Structural and functional investigation of cargo recognition by exportins
(2016-11-02)Nucleocytoplasmic exchange is essential for eukaryotic cells. It proceeds through nuclear pore complexes and is largely mediated by Importin β-like nuclear transport receptors (Impβ-like NTRs). According to the direction ... -
Mitochondrial protein assemblies: Biogenesis of the cytochrome c oxidase and mitophagic signaling complexes
(2016-09-05)Mitochondrial physiology requires a constant balance between biosynthesis and degradation events. This thesis addresses both mitochondrial biogenesis, exemplified by cytochrome c oxidase assembly, and mitochondrial removal ... -
Dynamic changes in cytochrome c oxidase assembly and organization
(2016-08-24)The respiratory chain in the inner membrane of the yeast mitochondrion is organized as a network of individual complexes and large supercomplex structures. These supercomplexes are composed of dimeric complex III and one ... -
Investigation of prokaryotic immune defense system with quantitative and structural mass spectrometry
(2016-02-26)Bacteria and archaea have evolved an adaptive and heritable immune defense system comprising a CRISPR (clustered regularly interspaced short palindromic repeats) locus and Cas (CRISPR-associated) proteins that targets ... -
Analysis of Mdm38 function in mitochondrial translation
(2015-11-05)The data presented in this thesis demonstrate that binding of Mdm38 to ribosomes has conserved characteristics in yeast and E. coli. To gain further insights into potential binding partners, an in vivo photo cross-linking ... -
Nuclear export of actin: A biochemical and structural perspective
(2015-08-18)Macromolecular exchange between the nucleus and the cytoplasm is mainly mediated by the RanGTP-dependent nuclear transport receptors (NTRs) of the Impβ family. NTRs are classified as importins and exportins according to ... -
Rab26 mediates selective targeting of synaptic vesicles to the autophagy pathway
(2015-02-26)In recent years it has been shown that macroautophagy regulates the turnover of postsynaptic receptors and modulates presynaptic neurotransmission. However it is still unclear whether the presynaptic protein turnover is ... -
Analysis of early steps in Assembly of Cytochrome c Oxidase
(2014-12-18)Cytochrome c oxidase (COX) is the terminal enzyme of the respiratory chain. Due to its multimeric nature, assembly and maturation requires the concerted action of over 20 assembly factors in yeast. COX is composed of both ... -
Residue level characterization of molecular interactions of intermembrane space domains governing the preprotein import into the mitochondrial matrix
(2014-12-10)Mitochondrial matrix targeting proteins are translated as preproteins (carrying an N-terminal 20-50 residue presequence) in the cytoplasm. Post-translationally, they are imported into the mitochondrial matrix through ... -
Exploration of cargo spectrum and NES patterns recognized by the exportin CRM1
(2014-10-15)The nuclear envelope (NE) subdivides eukaryotic cells into a nuclear and a cytoplasmic compartment, forcing material exchange between these two compartments to proceed through the nuclear pore complexes (NPCs). While ... -
Biochemical characterization of the Nup62⋅58⋅54 nucleoporin complex and mutational analysis of the exportin CRM1
(2014-10-15)Nuclear pore complexes (NPCs) are giant molecular machines embedded in the double membrane that surrounds the eukaryotic nucleus. Deciphering the molecular structure of the NPCs is critical to our understanding of both ... -
Systematic analysis of the interactome of modified chromatin
(2013-09-13)Regulation of chromatin composition and structure is crucial for maintaining genome integrity and execution of the wide array of functions related to gene regulation and downstream cell signaling. Chemical modifications ... -
Molecular characterization of Mst77F and implication in Drosophila spermatogenesis
(2013-04-19)The mechanisms of spermatogenesis, in particular the process of postmeiotic spermatid maturation, are little understood. During this developmental stage massive molecular and morphological rearrangements occur and the major ... -
Molecular mechanisms of lipid-rich myelin membrane sheet formation
(2013-02-13)Myelin is a membrane of vital importance. In the vertebrate nervous system, it promotes rapid conduction of nerve impulses via insulating the axons. To act as an insulator, myelin needs to assemble into a stable, lipid-rich ... -
Structural and Functional Analysis of the Mitochondrial Presequence Translocase
(2012-09-14)The yeast, Saccharomyces cerevisiae, mitochondrial proteome consists of approximately 1000 proteins, most of which are synthesized on cytosolic ribosomes and therefore require specialized transport systems to reach their ... -
The identification and characterization of Mio10 and MINOS1 as novel regulators of mitochondrial inner membrane organization
(2012-06-07)Various mitochondrial inner membrane proteins contribute to the structure of cristae membranes and to the overall dynamic morphology of the inner membrane. These proteins include the F1FOATPase dimers, which contribute to ... -
Identification of novel components involved in selective and unselective autophagic pathways
(2012-04-11)Autophagy is a ubiquitous protein degradation pathway in eukaryotic cells. As response upon nutrient starvation, cytosolic material and also whole organelles are engulfed by a double membrane-layered vesicle, the ... -
Yeast models to study mutations in SURF1 and MPV17 involved in human mitochondrial disorders
(2011-12-06)Mitochondrial diseases are fatal disorders mainly affecting highly energy dependent tissues such as brain, heart, liver and muscle. These severe disorders can be caused by mutations affecting mitochondrial- or nuclear-encoded ...