Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Rizzoli, Silvio Prof. Dr."
Now showing items 21-40 of 41
-
Quantification of forces involved in carbohydrate induced attachment of carcinoma cells
(2020-02-26)Vital biological processes such as the adhesion of cells to their surroundings rely on short-term recognition processes, which are defined by a rapid assembly and disassembly of adhesion molecules. These processes were ... -
Mechanisms of regulation of mitochondria-endoplasmic reticulum contact sites
(2019-11-19)In eukaryotic cells, inter-organelle communication is crucial for several cellular functions, as well as for several cell signaling mechanisms. Mitochondria and the endoplasmic reticulum (ER), for example, form tight contact ... -
Characterization of microglial Rab7 knockout on amyloid pathology in the 5xFAD mouse model of Alzheimer’s disease
(2019-11-08)Microglia are the innate immune cells of the brain. In neurodegeneration, such as Alzheimer’s disease, these cells are involved in clearance of cellular debris and extracellular aggregates of misfolded proteins like amyloid ... -
Dissection of the molecular machinery of micro- and macronucleophagy
(2019-11-07)A highly conserved pathway required for cellular homeostasis, autophagy facilitates degradation and recycling of various cellular components. Involvement of autophagy in medical context has made associated research a highly ... -
Collective Mechanical Behavior of Epithelial Cells - The Impact of Micro-Wounding
(2019-06-24)For epithelia, which are lining organs or blood vessels, the mechanical integrity of a whole cell sheet is indispensable. The question arises, how neighboring cells mechanically work together to build a functioning cell ... -
Dual-AAV mediated transfer of full-length otoferlin cDNA into auditory inner hair cells and the effects of different mutations in the OTOF gene on the protein levels and cellular distribution of otoferlin in auditory inner hair cells
(2019-05-08)Otoferlin is a large multi-C2 domain protein indispensable for hearing and synaptic transmission in auditory inner hair cells (IHCs). Mutations within the OTOF gene, coding for otoferlin, cause non-syndromic recessive ... -
Metabolism of oligodendrocytes and its involvement in axo‐glia interaction
(2019-03-12)In white matter, axonal energy homeostasis critically depends on glial support. Failure in glial-mediated delivery of metabolic substrates into the axonal compartment results in axonal energy deficit and may anticipate ... -
Identification of a unique oligodendrocyte subpopulation in mouse brain
(2018-10-10)Oligodendrocytes in the central nervous system (CNS) ensheath axons with myelin and are originated from migratory and proliferative progenitor cells, so-called oligodendrocytes progenitor cells (OPCs). While immunoreactivity ... -
The role of N-truncated Aβ peptides in Alzheimer’s Disease
(2018-06-29)The N-terminally truncated pyroglutamate Aβ3−42 (AβpE3−42) and Aβ4−42 peptides are known to be highly abundant in the brain of Alzheimer’s disease (AD) patients. Both peptides show enhanced aggregation and neurotoxicity ... -
Touching upon regulators of Piezo2 in mouse somatosensation
(2018-03-15)ABSTRACT Mechanosensation is an integral property of sensory systems like audition and somatosensation. The molecular determinants of mechanotransduction in mammals are only beginning to be understood. In 2010, Piezo2, a ... -
Regulation of the neuronal SNARE-complex by accessory proteins
(2018-02-16)In this work, I have thoroughly characterized a novel complex containing syntaxin1a (1-288), SNAP25a and Munc18-1 and established it as an efficient acceptor complex for synaptobrevin-binding, using several biochemical and ... -
Biochemical characterization of presynaptic membrane protein complexes
(2017-09-13)At chemical synapses, synaptic vesicles, membrane-enclosed entities filled with neurotransmitters, undergo exocytosis at restricted areas of the presynaptic membrane called active zones (AZ). The core AZ proteins form a ... -
Long-Term Temporal Dynamics of Synaptic Vesicles
(2017-09-11)Neurotransmission requires the release of neurotransmitters from synaptic vesicles. This occurs via fusion of the vesicle to the pre-synaptic membrane upon stimulation. However, not all synaptic vesicles are equally ... -
A comprehensive characterization of brain and retina synaptic vesicle proteome by quantitative mass spectrometry.
(2017-06-07)Synaptic vesicles (SVs) are essential organelles for the transfer of information between a pre-synaptic nerve terminal and a post-synaptic target. SVs release their neurotransmitter content into the synaptic cleft in a ... -
Molecular studies of the synaptic protein otoferlin
(2017-02-24)Deafness is an interesting and intensely studied topic and can be caused by different, genetic as well as environmental, factors. One important cause of deafness are mutations in the otoferlin gene leading to non-syndromic ... -
A Single Vesicle Assay to Study the Electrochemical Gradient Regulation in Glutamatergic and GABAergic Synaptic Vesicles
(2016-02-24)During neuronal activity, synapses sustain neurotransmission by a high fidelity multi-step process called synaptic vesicle (SV) recycling. This process involves endocytosis, neurotransmitter loading and exocytosis of SVs ... -
Lipid organisation and dynamics in the myelin membrane sheets
(2014-07-25)Myelin is a unique lipid-enriched membrane, produced by oligodendrocytes in the central nervous system, that is enwrapped around axons in the multilayered fashion to ensure a swift saltatory conduction of the neuronal ... -
Synaptic vesicle recycling investigated by high-resolution microscopy in a conventional and a sensory synapse
(2012-10-02)Synaptic neurotransmission depends on the action of highly specialized small secretory organelles – synaptic vesicles. At all chemical synapses the synaptic vesicles release in a strictly regulated fashion their neurotransmitter ... -
The accumulation of mutant p53 in human cancer cells
(2011-07-04)The tumor suppressor p53 is mutated in more than 50% of all human solid tumors. This comprises mostly single residue missense point mutations that entail a loss of p53 tumor suppressor ... -
A Micro-scope on intracellular trafficking
(2011-05-11)The general aim of this thesis work is to gain an encompassing insight into the intracellular trafficking machinery of multicellular organisms. For this purpose, the previously well-described ...