Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Rodnina, Marina Prof. Dr."
Now showing items 21-31 of 31
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Monitoring the late events of translation initiation in real-time
(2016-10-19)In bacteria, translation initiation is promoted by three initiation factors (IF1, IF2 and IF3) and entails three distinct steps. First, the small ribosomal subunit (30S) recruits the initiation factors, initiator tRNA ... -
Structure and Mechanism of the Flavoenzyme Lipoamide Dehydrogenase from Escherichia coli
(2016-08-29)The flavoenzyme lipoamide dehydrogenase (E3) is an ubiquitously distributed enzyme which is part of several multienzyme complexes involved in cellular carbon metabolism thus contributing to cellular homeostasis. It catalyzes ... -
Structural Survey on Cohesin and Viomycin Inhibited 70S Ribosome by Single Particle Electron Microscopy
(2016-04-21)Life can be understood as the systematic collaborative action of several entities on molecular level reducing locally the entropy at the cost of the exterior environment. These entities are in great part macromolecular ... -
Dynamic interactions during ribosome targeting to the membrane
(2015-05-11)The signal recognition particle (SRP) and its receptor are the main components of the co-translational protein targeting pathway by which membrane proteins are targeted to the membrane. The co-translational targeting pathway ... -
Strategies to stabilize RNP complexes for structural determination by 3D cryo-electron microscopy
(2014-10-24)The physiological reactions in a cell are generally not performed by single biological macromolecules, but by complexes of several molecules. They can be a complex of several proteins or can be composed of RNA and proteins ... -
Crystal Structure and Characterization of the SCOC Coiled Coil Domain
(2014-08-06)Autophagy is a conserved eukaryotic process for the degradation of cytosolic content. An expanding double layered membrane takes up part of the cytoplasm and matures to an autophagosomal vesicle. The autophagosome ... -
Functional characterization and application of 2',5'- branched RNA forming deoxyribozymes using lanthanides as cofactors
(2013-12-13)Deoxyribozymes or DNA catalysts are synthetic single stranded DNA molecules capable of catalysis for a wide range or reactions. Deoxyribozymes are discovered by in vitro selection and are mostly dependent on bivalent metal ... -
Structural and functional studies of the spliceosomal RNP remodeling enzyme Brr2
(2013-06-25)The spliceosome is a highly dynamic, multi-MDa eukaryotic RNA-protein (RNP) machinery that catalyzes precursor messenger RNA (pre-mRNA) splicing. Pre-mRNA splicing entails the excision of non-coding introns and the joining ... -
Identification of nuclear export signals and structural analysis of transport complexes.
(2013-01-09)The nucleus is a vital sub cellular compartment and it stores the genome. Transport across the nuclear envelope occurs through Nuclear Pore Complexes (NPC) and cargo traffic across the NPCs is a highly specific and ... -
Molecular mechanism of selenocysteine incorporation in bacterial translation
(2012-06-27)Selenocysteine is the 21st amino acid which is incorporated into proteins by recoding a stop codon UGA followed by a selenocysteine insertion sequence (SECIS) of the mRNA. In bacteria, selenocysteine insertion requires ... -
Structural and functional investigation of the protein synthesis in saccharomyces cerevisiae
(2012-02-24)Protein synthesis is an important house-keeping activity of all the cells. It follows the same concepts in all three domains of life: the genetic code is deciphered and transcribed into the ...