Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Schwappach, Blanche Prof. Dr."
Now showing items 21-26 of 26
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Transport of Tail-anchored Proteins to the Inner Nuclear Membrane
(2017-04-13)In contrast to the well-studied process of nucleocytoplasmic transport of soluble macromolecules, little is known about the targeting of integral membrane proteins to the inner nuclear membrane (INM), therefore the targeting ... -
Mitochondrial protein assemblies: Biogenesis of the cytochrome c oxidase and mitophagic signaling complexes
(2016-09-05)Mitochondrial physiology requires a constant balance between biosynthesis and degradation events. This thesis addresses both mitochondrial biogenesis, exemplified by cytochrome c oxidase assembly, and mitochondrial removal ... -
Orientation and organization of the presynaptic active zone protein Bassoon: from the Golgi to the synapse
(2016-08-30)Neurotransmitter release sites at the presynaptic terminus membrane, known as the active zones (AZs), are surrounded by synaptic vesicle pools and a dense network of five cytomatrix of the active zone (CAZ) proteins. At ... -
Non-Canonical Amino Acids as Minimal Tags for Investigating Protein Organization and Turnover
(2016-01-08)The burgeoning field of genetic code expansion provides new tools for specifically labeling proteins for a variety of applications. Clickable non-canonical amino acids (ncAA) have been refined for almost-quantitative and ... -
Multimolecular adaptor protein complexes in B cell receptor signaling
(2015-07-03)The activation of B cells is the crucial step of the humoral immune response. This process is controlled by the B cell receptor (BCR) signaling pathway which is initiated by antigen recognition. An elaborated and detailed ... -
Molecular mechanisms of collybistin-dependent gephyrin clustering at inhibitory synapses
(2014-07-03)Information processing and transmission in neuronal networks in the mammalian brain occurs through intercellular communication between neurons at synapses. Inhibitory synapses play a key role, for example to maintain network ...