Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Stülke, Jörg Prof. Dr."
Now showing items 21-36 of 36
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Functional characterisation of RNA helicases in the remodelling of pre-ribosomal subunits
(2018-07-13)DEAD/H-box RNA helicases are ubiquitously expressed enzymes, which are characterised by a conserved helicase core of two RecA-like domains containing sequence motifs required for substrate binding and hydrolysis of NTP. ... -
Interactions and functions of RNA-binding proteins
(2018-04-13)Alongside several well-known modifications in DNA and proteins, more than 100 different types of chemical modification are also found in cellular RNAs. RNA modifications can influence the secondary structure and interactions ... -
SubtiWiki 3.0: A relational database for the functional genome annotation of the model organism Bacillus subtilis
(2018-02-12)Biological databases emerged in the 1970s along with the rapid development of information science. Since then, they have greatly helped the research community in data management and information sharing, especially the model ... -
Vitamin B6 Production in Bacillus subtilis
(2018-01-23)Fermentative production of valuable goods is an economically competitive and ecologically sustainable alternative to chemical synthesis. Several previous studies have been dedicated to the establishment of vitamin B6 ... -
Characterization of RNA-modifying enzymes and their roles in diseases
(2017-11-29)More than 150 types of chemical modifications have been identified in cellular RNAs (collectively called ‘’the epitranscriptome’’), and such modifications have emerged as important regulators of gene expression. Despite ... -
Maintenance of glutamate homeostasis in Bacillus subtilis by complex regulatory systems and genomic adaptation
(2017-10-16)The Gram-positive model organism Bacillus subtilis lives in the soil and must cope with a constantly changing environment. Glutamate plays an important role in cellular metabolism, because it is the major amino group ... -
Analysis of the transcriptome of human NK lymphocytes
(2016-10-31)Natural Killer cells are large granular lymphocytes that contribute to both innate and adaptive immunity, as they can not only lyse infected cells or tumors, but also stimulate an adaptive immune response via production ... -
Structure-function relationships in wax producing enzymes
(2016-05-12)Wax esters (WEs) are esters of fatty acids and fatty alcohols. They can cover a broad range of physical properties, which makes them especially interesting for industrial applications, including additives in cosmetics and ... -
Investigation of prokaryotic immune defense system with quantitative and structural mass spectrometry
(2016-02-26)Bacteria and archaea have evolved an adaptive and heritable immune defense system comprising a CRISPR (clustered regularly interspaced short palindromic repeats) locus and Cas (CRISPR-associated) proteins that targets ... -
Control of glutamate homeostasis in the Gram-positive model organism Bacillus subtilis
(2015-10-22)Glutamate is a central metabolite in any living organism because it is the major amino group donor for nitrogen containing compounds. To ensure a constant glutamate supply, Bacillus subtilis tightly regulates glutamate ... -
Control of biofilm formation in Bacillus subtilis
(2015-05-12)Biofilms can be considered as one main lifestyle of many bacteria in their natural environment. A bacterial biofilm is a cell community that is surrounded by a self-produced extracellular matrix. This matrix usually consists ... -
Functional characterization of transketolase-like proteins and related model systems with respect to thiamin diphosphate mediated chemistry
(2014-11-12)Transketolases (TKTs, E.C 2.2.1.1) are ubiquitous distributed enzymes among all three domains of life. TKTs require thiamin diphosphate (ThDP) and bivalent cations as catalytic cofactors. They fulfill their catalytic ... -
Investigation of protein-RNA interactions by UV cross-linking and mass spectrometry: methodological improvements toward in vivo applications
(2014-04-07)Protein–RNA complexes play key roles in a variety of cellular functions such as gene expression and its regulation. One frequently applied method for the investigation of direct protein–RNA interactions is UV induced ... -
Functional characterization and application of 2',5'- branched RNA forming deoxyribozymes using lanthanides as cofactors
(2013-12-13)Deoxyribozymes or DNA catalysts are synthetic single stranded DNA molecules capable of catalysis for a wide range or reactions. Deoxyribozymes are discovered by in vitro selection and are mostly dependent on bivalent metal ... -
Regulatory interactions of enzymes of the citric acid cycle in Bacillus subtilis
(2013-01-25)In most organisms the tricarboxylic acid (TCA) cycle is a fundamental hub in metabolism. The TCA cycle is the origin and the endpoint of a broad spectrum of intermediates and provides the cell with energy and cellular ... -
The role of protein phosphorylation in regulation of carbon catabolite repression in Bacillus subtilis
(2008-11-20)CCR is one of the most thoroughly investigated signal transduction system in bacteria. It allows the bacteria to adapt to changes in the availability and supply of different carbon sources. ...