Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 1-20 of 1169
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13C sparse labeling for solid-state NMR investigations of biomolecular systems
(2014-12-16)This thesis refers to 13C sparsely labeled strategies, including protein structure characterization on two different biomolecular systems, to obtain structural information via 13C-13C and 13C-15N correlations by solid-state ... -
A comprehensive characterization of brain and retina synaptic vesicle proteome by quantitative mass spectrometry.
(2017-06-07)Synaptic vesicles (SVs) are essential organelles for the transfer of information between a pre-synaptic nerve terminal and a post-synaptic target. SVs release their neurotransmitter content into the synaptic cleft in a ... -
A comprehensive study of the adult mouse brain transcriptome: analysis of inter-individual differences in cognitive aging and cell-type specific changes in the hippocampus upon voluntary exercise
(2023-12-19)The hippocampus (HPC) is a brain region crucial for learning and memory processes, and this link between the HPC and cognition has been extensively studied in recent decades. Previous research has demonstrated that external ... -
A cortical hierarchy for differential GABAergic circuit motifs as targets for stress-induced alterations in endocannabinoid signaling
(2021-09-17)Aberrant endocannabinoid (eCB) signaling has been implicated in the pathophysiology of different stress-related psychiatric diseases, such as schizophrenia, depression, and anxiety disorders. Such eCB signaling is triggered ... -
A crosstalk between NF-κB and STAT1 signal transduction pathways in ischemic and proliferative diseases
(2024-07-08)The cytokine-driven transcription factor STAT1 (signal transducer and activator of transcription 1) executes anti-microbial and pro-apoptotic functions, while loss-offunction mutations in the STAT1 gene are associated with ... -
A Functional Characterisation of Drosophila Chordotonal Organs
(2013-06-27)Functional properties of the Drosophila FCO (femoral chordotonal organ) can be dissected by use of the Gal4-UAS system in combination with transcuticular in vivo Calcium imaging. As sinusoidal stimulation at relative ... -
A guardian of balance: the role of BAF chromatin remodeling complex in astrogliogenesis during mouse forebrain development
(2019-12-20)In the human central nervous system, astrocytes vastly outnumber neurons and regulate a host of physiological processes critical to its function. Astrocytes form a functional syncytium tiling the brain with minimal overlap ... -
A light-inducible Na+ pump to study the role of intracellular Na+ accumulation in heart failure
(2024-10-10)Elevated Nai levels have been identified as a significant factor in the development of heart failure, observed across multiple species. This is caused by downregulated NKA, increased NHE activity and elevated late Na+ ... -
A Micro-scope on intracellular trafficking
(2011-05-11)The general aim of this thesis work is to gain an encompassing insight into the intracellular trafficking machinery of multicellular organisms. For this purpose, the previously well-described ... -
A mifepristone-regulated adeno-associated viral vector system for regulated neurotrophic factor expression in the central nervous system.
(2013-07-03)Parkinson’s disease (PD), the second most common neurodegenerative disease in the western society, affects more than 1% of the population and its impact on the society increases with the increasing average age. Current ... -
A Minimal Approach to the Dynamic Regulation of Biomolecular Conformation
(2022-12-14)Allostery is the key mechanism enabling a “remote” regulation of the activity of proteins and other biological macromolecules. It forms the basis for controlling various inter- and intracellular processes. Allosteric ... -
A Mitotic Actin Regulating Pathway Induces Chromosomal Instability In Human Cancer Cells
(2020-06-11)Chromosome instability (CIN) is a hallmark of human cancer and causes structural (S-CIN) as well as whole (W-CIN) chromosome aberrations. Cancers exhibiting the CIN phenotype are characterized by a large genetic heterogeneity ... -
A Multidisciplinary Approach to Neuropathic Pain: Assessing Tactile Sensation and Neuroma Pain Factors
(2023-07-18)Neuropathic pain is a complex and often debilitating condition. Distally from the injury site, missing input contributes to deafferentation pain, while proximally, neuroma formation leads to peripheral and central ... -
A novel function of DPP9 in DNA damage repair via BRCA2 regulation
(2019-01-25)Eukaryotic cells are constantly exposed to exogenous and endogenous agents that induce mutational stresses in their genome, which can lead to genetic lesions, such as chromosome loss, translocations or deletions. The ... -
A novel membrane-binding probe for the morphological and molecular characterization of synaptic vesicle recycling pathways
(2015-05-12)An important anatomical feature of neuronal synapses is the presynaptic bouton, a structure that isolates synaptic vesicle recycling from constitutive membrane trafficking pathways. However, in some neurotransmitter-releasing ... -
A novel phosphatase modulating the DNA damage response and the tumor suppressor p53
(2011-09-21)The cellular genome is constantly exposed to harmful endogenous and exogenous factors. Unrepaired DNA lesions and mismatches promote genomic instability, a major cause of cancer. Therefore, ... -
A novel role for the E3 ubiquitin ligase FBXO7 in axon-myelin interaction
(2018-06-06)The regulated turnover of proteins is an essential aspect of every cell. Cells must be able to respond to environmental changes or undergo different developmental stages, while still maintaining a balanced protein homeostasis. ... -
A nuclear export sequence in Nup214 promotes its targeting to the nuclear pore complex
(2020-10-29)The nuclear pore complex (NPC) controls the communication between the nucleus and the cytoplasm in a selective manner via a hydrophobic barrier involving phenylalanine-glycine (FG) repeats. Interactions with components of ... -
A pilot study assessing neurophysiological and cardiovascular effects of non-invasive vagus nerve stimulation in healthy subjects and patients with restless legs syndrome
(2023-08-31)Background: Transcutaneous auricular vagus nerve stimulation (taVNS) is an auspicious neurostimulation technique intensively investigated for its potential antidepressant, anticonvulsive, anti-inflammatory and analgesic ... -
A possible functional link between RNA degradation and transcription in Bacillus subtilis
(2020-09-24)Cellular levels of RNA depend on the rate of its synthesis and degradation. While synthesis is performed by RNA polymerase conserved in all domains of life, the enzymes responsible for RNA degradation are more unique ...