Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 94-113 of 1169
-
BACE1 dependent function of Neuregulin1 in peripheral nervous system myelination
(2010-05-26)The neuronal epidermal growth factor (EGF)-like growth factor NRG1 type III serves as a master regulator of myelination in the peripheral nervous system (PNS). It has been proposed that ... -
BAF155 regulates the genesis of basal progenitors through both Pax6-dependent and independent mechanisms during cerebral cortex development
(2018-04-10)During mammalian development, the balance between symmetric and asymmetric division of radial glial (RG) progenitors regulates the tangential size versus radial growth of the cerebral cortex. The pool of basal progenitors ... -
Basic coding activities of populations of Xenopus laevis olfactory receptor neurons recorded with a fast confocal line illumination microscope
(2013-09-05)The olfactory system is able to sample a large odor space with only a limited number of olfactory receptor neurons (ORN) using so-called combinatorial coding. Here, different ORN classes exhibit a broad but specific odor ... -
Bayesian Inference for Top-Down Protein Markov Models and the Ubiquity of Michaelis-Menten Kinetics
(2024-10-04)The current understanding of protein function predominantly relies on the concept of describing proteins as comprising discrete conformational and chemical states including transitions between these states. The theory of ... -
Bayesian Structural Ensemble Determination from Single-Molecule X-ray Scattering
(2024-02-09)Single-molecule X-ray scattering experiments using ultrashort X-ray free electron laser (XFEL) pulses have opened a new route for the structure determination of biomolecules. They also hold the potential to extract the ... -
Behavioral analyses in translational neuropsychiatric research
(2024-07-05)Cognitive impairment frequently co-occurs in a variety of neuropsychological disorders, making it an increasing burden to the affected individuals, their relatives, and society in general. Diagnostic procedures usually ... -
Bildung und Homöostase von c-di-AMP in Bacillus subtilis
(2014-07-14)Signal transduction describes the ability of cells to sense environmental stimuli and transfer this information in order to react appropriately to these stimuli. In this process, signaling nucleotides are often important. ... -
Biochemical analysis of CYP74-enzymes in Physcomitrella patens
(2014-03-18)In this study recombinant CYP74-enzymes AOS1, AOS2 and HPL from the moss P. patens, DES from S. tuberosum and EAS from the lancelet B. floridae were expressed in E. coli and purified for further analysis. PpAOS1 and BfEAS ... -
Biochemical and functional differences of chromatin assembled replication-coupled or independent in Xenopus laevis egg extracts
(2012-04-12)Two main chromatin assembly pathways ensure the proper transmission of chromatin organization and chromatin-based information throughout the cell cycle. A replication-dependent (RD) pathway that couples chromatin assembly to ... -
Biochemical Characterization and Engineering of L-asparaginases for Amino Acid Depletion Therapy of Acute Lymphoblastic Leukemia
(2014-06-25)The goal of the present work was to form a basis for the development of improved protein therapeutics against acute lymphoblastic leukemia (ALL). Bacterial L-asparaginases, in combination with other chemotherapeutics, are ... -
Biochemical Characterization of Human Guanylate Kinase and Mitochondrial Thymidine Kinase: Essential Enzymes for the Metabolic Activation of Nucleoside Analog Prodrugs
(2015-07-28)Deoxyribonucleoside and nucleotide kinases are key enzymes that catalyze the critical phosphorylation steps in the conversion of antiviral and anticancer nucleoside analogs to their corresponding cytotoxic nucleoside ... -
Biochemical characterization of presynaptic membrane protein complexes
(2017-09-13)At chemical synapses, synaptic vesicles, membrane-enclosed entities filled with neurotransmitters, undergo exocytosis at restricted areas of the presynaptic membrane called active zones (AZ). The core AZ proteins form a ... -
Biochemical characterization of the Nup62⋅58⋅54 nucleoporin complex and mutational analysis of the exportin CRM1
(2014-10-15)Nuclear pore complexes (NPCs) are giant molecular machines embedded in the double membrane that surrounds the eukaryotic nucleus. Deciphering the molecular structure of the NPCs is critical to our understanding of both ... -
Biochemical reconstitution of human autophagy initiation
(2023-05-04)Autophagy is a tightly regulated process that eukaryotic cells use as a major survival mechanism to reallocate nutrients to essential processes in adverse conditions such as nutrient or energy deprivation. Autophagy is ... -
Biogenesis and maintenance of cytoplasmic domains in myelin of the central nervous system
(2017-02-27)Myelin is a multi-lamellar membrane structure, produced by oligodendrocytes which are special glial cells, that myelinate axons in the central nervous system (CNS) (Aggarwal, Yurlova, & Simons, 2011; Vassall, Bamm, & Harauz, ... -
Biogenesis of Lipid Bodies in Lobosphaera incisa
(2017-02-28)Microalgae hold great promise with regards to the production of valuable products such as PUFAs and biofuel. They are a highly interesting group of organisms for investigating lipid metabolism and while some insight has ... -
Bioinformatics analysis of multi-omics data elucidates the primary function of Oct4 in gene regulation and pluripotency maintenance
(2022-03-14)The transcription factor (TF) Oct4 is essential for maintaining pluripotency in vitro as well as in vivo. The crucial function of Oct4 in control of pluripotency has been extensively studied during reprogramming of somatic ... -
Bioinformatics analysis of multi-omics data elucidates U2 snRNP function in transcription
(2021-08-16)Transcription by RNA polymerase II (Pol II) is an important step in cell function and regulation. Pol II transcription has been shown to be coupled to pre-mRNA splicing, but the underlying mechanisms remain poorly ... -
Biophysical and Crystallographic Characterization of Spliceosomal DExD/H-box ATPases
(2020-04-23)DEAH-box ATPases play a vital role in the activation, catalytic and disassembly steps of the spliceosome. They are key for the orchestration of conformational and compositional rearrangements during the splicing cycle. It ... -
Biophysical and molecular mechanisms of mean and variance adaptation in the Drosophila ear
(2023-05-16)Adaptation is an important mechanism found across sensory systems and species. This important ability of sensory systems expands our range of perception. Giving us the ability to perceive a quiet whisper as well as a loud ...