Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title

Catalysis at the Interface- Elucidation of the Activation Process and Coupling of Catalysis and Compartmentalization of the Peripheral Membrane Protein Pyruvate Oxidase from Escherichia coli

Sitte, Astrid (2014-02-06)

The thiamine- and flavin-dependent peripheral membrane protein pyruvate oxidase from E. coli (EcPOX) catalyzes the oxidative decarboxylation of the central metabolite pyruvate to CO2 and acetate with a concomitant electron ...

Cell and Receptor Tropism of γ2-Herpesviruses

Großkopf, Anna Katharina (2021-02-25)

Kaposi’s sarcoma-associated herpesvirus (KSHV), the only rhadino- or γ2-herpesvirus of humans, is associated with Kaposi’s sarcoma (KS) and two B cell proliferative malignancies, primary effusion lymphoma (PEL) and a ...

Cellular dynamics and stable chaos in balanced networks

Puelma Touzel, Maximilian (2016-01-22)

A prudent approach to understanding the function of the cerebral cortex begins with understanding the repertoire of its dynamics. In this thesis, I study how interactions between single neuron properties, synaptic coupling, ...

Cellular function and toxicity of the Parkinson’s disease-related genes α-synuclein and catp-6 in C. elegans

Wender, Nora (2013-04-09)

Parkinson’s disease (PD) is the second most common neurodegenerative disease in industrialized countries. However, the molecular mechanisms leading to neuronal death in PD still remain unclear. About 5-10% of PD patients ...

Cellular locomotion and adhesion in the context of different substrate properties

Baronsky, Thilo (2017-01-16)

This work comprises three different projects dealing with the interplay of cellular locomotion and adhesion to establish a better understanding of the response of cells to their environment. In the first part of this thesis ...

Cellular mechanisms of odor detection in the olfactory system of the red flour beetle Tribolium castaneum

Montino, Alice Christine (2015-10-26)

Olfaction, the detection of odors is pivotal for insects, since it leads them to food sources or mating partners and triggers important behaviors. For the detection of pheromones, CD36-related sensory neuron membrane ...

Cellular stress induces RIS dependent sleep and ALA dependent sedation via EGF receptor signaling in Caenorhabditis elegans

Konietzka, Jan (2019-07-15)

Why do we sleep? This question is still unsolved, although sleep is such a fundamental behavioral state in all organism with a nervous system. Several physiological mechanisms, like memory consolidation, metabolic waste ...

Central sound encoding in the inferior colliculus of mouse models for human auditory synaptopathy and neuropathy

Pelgrim, Maike (2018-12-20)

Auditory neuropathy and auditory synaptopathy are hearing disorders with normal outer hair cell function and cochlear amplification, but an impairment in the function of inner hair cells, their ribbon synapses, or in the ...

CFM: Confinement Force Microscopy-a dynamic, precise and stable microconfiner for traction force microscopy to study confined cell behaviour

Abbasi, Fatemeh (2024-01-11)

Physical properties of the 3D microenvironment and the residing tissue affect cell behavior and function. 3D environment represents major physical obstacles for cell migration, such as spatial confinement, which could ...

Changes in gene expression linked to Alzheimer's disease and "healthy" cognitive aging

Navarro Sala, Magdalena (2019-02-20)

Alzheimer’s disease (AD) is a neurodegenerative disease and the most common form of dementia. The number of AD cases increases exponentially every year. Although AD has been investigated for a long time, the precise ...

Chaotic Dynamics in Networks of Spiking Neurons in the Balanced State

Monteforte, Michael (2011-05-30)

The brain processes sensory information about the outside world in large complex networks of neurons which communicate with short electrical pulses called action potentials or spikes. The ...

Chaotic Neural Circuit Dynamics

Engelken, Rainer (2018-02-09)

Information is processed in the brain by the coordinated activity of large neural circuits. Yet, we are still only starting to understand how this high-dimensional complex system gives rise to functions such as processing ...

Characterisation of CD4+ stem cells of the skin and their role in skin homeostasis and tumourigenesis

Brandes, Nadine (2021-06-03)

The skin represents the largest organ of the mammalian body and acts as the primary barrier against environmental stressors. Cellular maintenance and regeneration of the skin is orchestrated by a variety of skin stem ...

Characterisation of killer immunoglobulin-like receptors in rhesus macaques (Macaca mulatta)

Hermes, Meike (2012-10-22)

Rhesus macaques are important animal models of human diseases in which NK cells play significant roles. Whereas data on KIR genetic variability were recently published, data on KIR protein expression was not available until ...

Characterisation of primate primordial germ cells in vitro

Kurlovich, Julia (2024-06-17)

Primordial germ cells (PGCs) are embryonic precursors of sperm and eggs, responsible for passing on genetic and epigenetic information throughout the generations. For certain mammalian species, the development of PGCs can ...

Characterization of abundant unknown proteins that participate in the control of tRNA maturation and fatty acid acquisition in Bacillus subtilis

Wicke, Dennis (2024-07-23)

Despite tremendous advances in sequencing and other state-of-the-art technologies, unknown proteins are present in virtually all living organisms. Even though Bacillus subtilis is one of the most extensively annotated model ...