Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 225-244 of 1169
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Damage and Repair in Experimental Cortical Demyelination
(2010-11-04)Remyelination represents an important self repair mechanism in demyelinating diseases such as multiple sclerosis (MS). The intrinsic regenerative potential of the cerebral cortex is ... -
Data Integration of High-Throughput Proteomic and Transcriptomic Data based on Public Database Knowledge
(2017-05-17)With the advance of high-throughput methods enabling deep characterization of the cell on different cellular layers, ideas to combine different data types for inference of regulatory processes have emerged. Such integration ... -
Decoding and influencing mitochondrial inner membrane ultra-structure biogenesis
(2022-04-28)The Mitochondrion is a ubiquitous organelle known to be involved in a variety of vital cellular functions besides its central role in ATP synthesis such as, cellular metabolism, signalling and apoptosis. Dynamic in both ... -
Decoding Cortical Motor Goal Representations in a 3D Real-World Environment
(2018-10-10)In sensorimotor neuroscience a certain motor behavior, and its underlying neuronal mechanism, is usually studied in isolation and tightly constrained by the experimental setting to provide interpretable results. When ... -
Decoding the Epigenome of Neuronal Networks in Health and Disease
(2019-05-27)Alzheimer’s disease (AD) is the most prevalent form of dementia that has vast emotional and economic implications in our society. There is no cure for this neurodegenerative disorder as the pathological changes occur years ... -
Defense remodelling by ectomycorrhizal fungi in non-hosts
(2020-08-04)Root colonizing beneficial microorganisms promote growth of host plants and protect them against biotic threats. These microbes are considered as sustainable replacements for the hazardous chemical treatments in agriculture. ... -
Dense-core vesicle maturation at the Golgi-endosomal interface in Caenorhabditis elegans
(2012-06-08)Fast synaptic transmission is mediated by the triggered release of neurotransmitters from synaptic vesicles (SVs). To regulate synaptic transmission and neuronal activity, neurons also release neuropeptides and hormones ... -
Dependency of 3D chromatin folding on RNA polymerase II at different cell cycle stages
(2023-07-13)In human cells, the genetic information is organised in a multilayer fashion. During the cell cycle, chromatin undergoes dramatic structural changes. For proper inheritance, chromatin is compacted to chromosomes in ... -
Design strategies for carbon nanotube-based biosensors
(2020-07-09)Global health crises such as the COVID-19 pandemic clearly show the need for novel and better diagnostic and therapeutic tools. Additionally, understanding underlying molecular processes is crucial. However, current methods ... -
Detection and functional analysis of Ca2+ microdomains and BK channels in olfactory receptor neurons of larval Xenopus laevis
(2011-09-21)Olfactory receptor neurons (ORNs) sense odors through the interaction of odorants with their receptors, accomplishing the first step of olfactory signaling via the generation of action ... -
Determination of the Dynamic Gain Function of Cortical Interneurons with distinct Electrical Types
(2017-04-25)In the living brain, individual neurons are constantly bombarded by thousands of synaptic inputs, which results in a fluctuating membrane potential. Neurons under such conditions are said to operate in a “fluctuation-driven ... -
Developing tools for translational In-vivo cochlear optical stimulation
(2024-07-02)Utilizing optogenetic stimulation to target type I spiral ganglion neurons (SGNs) could promise an alternative to the currently employed electrical stimulation by current cochlear implants (CIs). Given light's spatial ... -
Development and Application of CP-ENDOR Spectroscopy on Protein Radicals
(2020-03-09)Electron-nuclear double resonance (ENDOR) spectroscopy is the method of choice for detecting magnetic nuclei in biomolecules which contain an unpaired electron spin. However, due to its low gyromagnetic ratio, the detection ... -
Development and characterization of novel reversibly switchable red fluorescent proteins with opposing switching modes
(2020-03-03)Since the discovery of the green fluorescent protein (GFP) from the jellyfish Aequorea victoria, a multitude of fluorescent proteins have been derived from the original GFP and its homologs by protein engineering. Their ... -
Development of 13C Liquid State Dynamic Nuclear Polarization at 9.4 Tesla
(2023-07-11)Throughout the last decades, nuclear magnetic resonance (NMR) spectroscopy in liquids contributed to the structural elucidation of molecules of many types and sizes. Continuous improvements of the hardware and pulse sequences ... -
Development of a multiplexed RNAi-coupled sensor assay to study neuronal function on the large-scale
(2017-07-24)Psychiatric diseases such as schizophrenia, bipolar disorder and autism spectrum disorders are considered neurodevelopmental synaptopathies. Compelling evidence obtained from large-scale genome-wide association studies, ... -
Development of a statistical framework for mass spectrometry data analysis in untargeted Metabolomics studies
(2014-12-11)A central objective in the analysis of mass spectrometry-based untargeted Metabolomics data is the detection of intensity patterns that differ between experimental conditions and the identification of underlying metabolites ... -
Development of a versatile microfluidic platform to study the ionic mechanisms of vesicular neurotransmitter transporters
(2021-11-04)This thesis described the development of a novel, versatile microfluidic platform for studying the ionic mechanisms of vesicular neurotransmitter transporters in rodent synaptic vesicles (SVs). The level of filling of an ... -
Development of a ‘tool box’ for generating designer nucleosomes in high throughput fashion
(2017-11-23)Post-translational modifications of histones within nucleosomes regulate cell development, cell maintenance and cellular response to external factors. According to the histone code hypothesis, each biologic reaction is ... -
Development of Advanced Acquisition and Reconstruction Techniques for Real-Time Perfusion MRI
(2017-01-09)This thesis concentrates on methodological developments in both acquisition and reconstruction techniques when applying concepts from real-time imaging to the field of dynamic contrast-enhanced magnetic resonance imaging. ...