Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 372-391 of 1164
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GABA and glycine co-transmission in the developing mouse respiratory network
(2014-11-18)Inhibitory neurons in the pre-Bötzinger complex - a kernel for respiratory rhythm generation, are involved in the respiratory rhythm modulation. The co-transmission of GABA and glycine has been reported in different brain ... -
Gbp2 and Hrb1 continue their mRNA quality control in the cytoplasm and take part in Nonsense Mediated Decay
(2019-09-02)The eukaryotic mRNA life cycle is orchestrated by many pathways. Every aspect of this life cycle is associated with quality control factors. This tight coupling of mRNA transcription, processing, export and translation ... -
Gemcitabine Resistance Elicits a Calcium Dependent Epigenetic Reprogramming in Pancreatic Cancer
(2021-03-08)Pancreatic cancer is a dismal malignancy with a 5-year survival rate of 7-9%, one of the worst among all cancer types. Patients with pancreatic ductal adenocarcinoma (PDAC) usually present an advanced stage of the disease ... -
Gene Expression Analysis in Models of Cognitive Diseases
(2023-04-18)Neuropsychiatric disorders and neurodegenerative diseases have been a subject of significant interest in the scientific community for several reasons. A considerable portion of the population experiences discomfort due to ... -
Gene expression divergence during Drosophila head development on single nuclei resolution
(2023-11-01)In this work, I optimized single-nuclei and single-cell RNA sequencing protocols for working with small amounts of input tissue. Using one of these protocols, I generated 14 single-nuclei RNA expression datasets. These ... -
Gene Ontology-based framework to annotate genes of hearing
(2013-10-22)As the number of discovered deafness genes and our knowledge about their role in hearing continuously increases, the need to accurately manage this genetic information is becoming more apparent. Gene Ontology (GO) is a ... -
Generation and analysis of T cell receptor transgenic rats to model CNS autoimmunity
(2014-01-27)Autoreactive T cells directed against CNS antigens seem to play an essential role at least in the initiation of multiple sclerosis. To improve our understanding about the function of pathogenic T cells in CNS autoimmunity ... -
Generation principles for arm movements in humans
(2012-06-14)This thesis comprises studies on the two major domains of motor control – posture and movement – with special focus on human upper limbs. Endeffector stiffness characterises the resistance of the arm against external ... -
Genetic and autoimmune modulators of brain function in neuropsychiatric illness and health
(2018-06-15)In the present thesis, the synergetic interaction between the nervous and immune systems and the potential pathological outcomes mediated by autoimmune processes targeting the brain was addressed, with a particular focus ... -
Genetic determination and layout rules of visual cortical architecture
(2017-08-30)The functional architecture of the primary visual cortex is set up by neurons that preferentially respond to visual stimuli with contours of a specific orientation in visual space. In primates and placental carnivores, ... -
Genetic interaction of Per- and Dec-genes in the mammalian circadian clock
(2011-12-07)Many behavioural and physiological processes in mammals display circadian (24 hour) rhythms controlled by an internal timekeeping system the circadian clock. The pacemaker of the circadian ... -
Genetic manipulation of CNS cholesterol metabolism and its effects on cerebral β-amyloidosis
(2019-03-07)Accumulating evidence implicates cholesterol metabolism in the pathogenesis of Alzheimer’s disease (AD). However, the underlying mechanisms are not well understood. In the brain, cholesterol is synthesized locally by ... -
Genetic Targeting and Analysis of Parvalbumin and VGLUT3 Expressing Inhibitory Interneurons
(2012-03-12)GABAergic interneurons are a highly diverse class of cell types that play essential roles in regulating the input/output behaviour of pyramidal neurons and of other interneurons. Thereby, ... -
Genetics of Drosophila hearing
(2013-10-04)By probing Johnston’s organ function in mutant fly strains, mutations in forty-four genes that affect Drosophila hearing have been identified. This result increases the list of genes that are known for audition by 180 % ... -
Genome-wide analysis of mutually exclusive splicing
(2013-02-14)In recent years, advances in sequencing techniques resulted in an explosive increase in sequencing data. Here, computational methods and bioinformatical analyses are presented that provide approaches to keep pace with the ... -
Genomics and Phylogeny of Cytoskeletal Proteins: Tools and Analyses
(2013-02-05)Evolution of the eukaryotic dynactin complex, the activator of cytoplasmic dynein: Background Dynactin is a large multisubunit protein complex that enhances the processivity of cytoplasmic dynein and acts as an adapter ... -
Genomics of Hybridization and Adaptation in Primates
(2023-12-07)In chapter 1, we used high coverage (30X) whole genome sequences from 225 wild baboons (genus Papio) representing 19 geographic localities to investigate population genomics and inter-species gene flow. Our analyses provide ... -
Geophysical Pattern Formation of Salt Playa
(2019-03-21)Patterns, such as the hexagonal salt ridges that emerge in salt deserts around the world, are a common phenomenon in geophysical settings. They are similar to other natural phenomena such as fairy circles, columnar joints ... -
Giant plasma membrane vesicle-derived in vitro systems to study the structure and dynamics of CaV1.3 channel clusters
(2023-11-06)The voltage-gated calcium channel 1.3 (CaV1.3) has plentiful tasks in the human body. One of them is the excitation-contraction coupling within the heart, where it is known to form CaV1.3 channel cluster. However, their ... -
Glomerular information processing in Xenopus laevis
(2016-08-30)Olfactory glomeruli are structural and functional neuropils in the olfactory bulb. Although many olfactory receptor neurons (ORNs) project to one glomerulus, stimulusinduced responses within single glomeruli could not ...