Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 396-415 of 1165
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Head versus tail: germ cell-less initiates axis formation via homeobrain and zen1 in a beetle
(2018-08-27)The iBeetle screen project: Christiane Nüsslein-Volhard and Eric Wieschaus performed the first saturated forward genetic screen using random mutagenesis to identify genes important for embryonic development in Drosophila ... -
Hemisphere and region - specific effects of chronic stress in the rat prefrontal cortex
(2007-05-03)This thesis demonstrated that pyramidal neurons of the prelimbic and infralimbic area of the rat prefrontal cortex had an intrinsic morphological asymmetry in that pyramidal neurons in the ... -
High-bandwidth microrheology of cytoskeletal networks
(2012-02-08)The understanding of the material properties, the organization and the assembly of the cytoskeleton remains challenging. In this thesis the viscoelastic properties of cytoskeletal networks ... -
High-resolution structure determination of human spliceosome complexes by cryo-EM
(2019-02-14)The eukaryotic splicing of precursors to mRNA is facilitated by a highly dynamic, multi-megadalton macromolecular machine termed the spliceosome. The underlying chemical reaction features the excision of an intron, which ... -
Higher-Dimensional Extensions of Nonlinear Inverse Reconstruction for Magnetic Resonance Imaging
(2020-02-05)Even though magnetic resonance imaging (MRI) has become progressively faster in recent years, acquisition speed is still a problem in current clinical settings. Physiological constraints such as gradient-induced peripheral ... -
How introgressive hybridization shaped a genus' phylogeny
(2010-06-24)Primates are a diverse order, which exhibits numerous behavioral and morphological traits. To elucidate the evolutionary history of those traits an understanding of the phylogeny of the ... -
How nonlinear processing shapes natural stimulus encoding in the retina
(2022-05-31)Understanding natural vision is one of the fundamental goals of sensory neuroscience. The only part of the visual system that may currently be amenable to such a complete understanding is the vertebrate retina, where there ... -
Huntingtin toxicity is ameliorated by BAG1 through modulation of its aggregation, degradation and subcellular distribution
(2009-02-23)Huntington s disease (HD) is a fatal neurodegenerative disorder resulting from an expansion of a polyglutamine stretch in a ubiquitously expressed protein called huntingtin. Intraneuronal ... -
Hydrodynamics of Ciliary Systems
(2023-08-15)The interactions of cilia with one another and their environment are central to many important questions in biology. These hairlike organelles are found in motile and immotile (or `primary') variants, and have a variety ... -
Identification and Analysis of Gene Product Modifiers of α-Synuclein Toxicity in the Fruit Fly (D. Melanogaster).
(2010-09-22)Parkinson s disease (PD) is a progressive neurodegenerative disorder, pathologically characterized by loss of dopaminergic neurons in the substantia nigra pars compacta. Various mutations ... -
Identification and analysis of JAK/STAT pathway target genes in Drosophila melanogaster
(2009-07-30)The JAK/STAT signalling cascade is one of the most conserved pathways in the animal kingdom. Aside from its developmental roles, the JAK/STAT pathway is needed for stem cell maintenance, ... -
Identification and Characterisation of Lipid Droplet-Localised Proteins
(2021-03-16)Lipid droplets (LD) are unique organelles, whose physiological relevance has been underestimated for a long time. Well-known in seed tissues for storing triacylglycerol (TAG) to fuel post-germinative seedling establishment, ... -
Identification and characterization of ADNP as a novel heterochromatin component
(2011-03-29)In eukaryotic cells genetic information in the form of long linear DNA fibers is stored in the cell nucleus. Time and tissue specific gene expression patterns are manifested by the combination ... -
Identification and Characterization of Importin 13 Substrates
(2018-05-09)Nuclear pore complexes embedded in the nuclear envelope regulate the bidirectional transport of macromolecules between the nucleus and the cytoplasm. Small molecules can rapidly move through the permeability barrier of the ... -
Identification and characterization of molecular mechanisms driving the functional specification of motor neurons The Delta like homolog 1 protein
(2012-03-02)Spinal Motor neurons are playing a decisive role in body posture and locomotion by controlling skeletal muscle contraction via their motor axon termini. During embryonic development motor ... -
Identification and characterization of plant lipid droplet-associated proteins
(2024-02-23)The molecular study of plant lipid droplets, first described over a century ago, has garnered attention since the identification of oleosins in the 1980s’. In recent years, considerable progress has been achieved in ... -
Identification and functional characterization of PTK7 ligands in Xenopus laevis
(2011-10-26)Wnt signaling pathways are evolutionary conserved and regulate numerous processes in both developing and adult organisms. The canonical Wnt signaling pathway regulates cell proliferation ... -
Identification of a novel subnetwork involved in eye size variation between Drosophila melanogaster and D. mauritiana
(2022-04-07)The Mendelian genetics concept relies on simple genotype-phenotype relationships with few genes having major effects on the phenotype. However, many traits evolve by a combination of variation in many genomic loci with ... -
Identification of a septin filament required for CNS myelin integrity
(2014-04-14)Axonal integrity and longevity require functionally intact myelin, as demonstrated by the deletion of myelin-specific genes in mice. To identify molecules that contribute to the structural organization of CNS myelin, its ... -
Identification of a unique oligodendrocyte subpopulation in mouse brain
(2018-10-10)Oligodendrocytes in the central nervous system (CNS) ensheath axons with myelin and are originated from migratory and proliferative progenitor cells, so-called oligodendrocytes progenitor cells (OPCs). While immunoreactivity ...