Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 407-426 of 1169
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Identification and Analysis of Gene Product Modifiers of α-Synuclein Toxicity in the Fruit Fly (D. Melanogaster).
(2010-09-22)Parkinson s disease (PD) is a progressive neurodegenerative disorder, pathologically characterized by loss of dopaminergic neurons in the substantia nigra pars compacta. Various mutations ... -
Identification and analysis of JAK/STAT pathway target genes in Drosophila melanogaster
(2009-07-30)The JAK/STAT signalling cascade is one of the most conserved pathways in the animal kingdom. Aside from its developmental roles, the JAK/STAT pathway is needed for stem cell maintenance, ... -
Identification and Characterisation of Lipid Droplet-Localised Proteins
(2021-03-16)Lipid droplets (LD) are unique organelles, whose physiological relevance has been underestimated for a long time. Well-known in seed tissues for storing triacylglycerol (TAG) to fuel post-germinative seedling establishment, ... -
Identification and characterization of ADNP as a novel heterochromatin component
(2011-03-29)In eukaryotic cells genetic information in the form of long linear DNA fibers is stored in the cell nucleus. Time and tissue specific gene expression patterns are manifested by the combination ... -
Identification and Characterization of Importin 13 Substrates
(2018-05-09)Nuclear pore complexes embedded in the nuclear envelope regulate the bidirectional transport of macromolecules between the nucleus and the cytoplasm. Small molecules can rapidly move through the permeability barrier of the ... -
Identification and characterization of molecular mechanisms driving the functional specification of motor neurons The Delta like homolog 1 protein
(2012-03-02)Spinal Motor neurons are playing a decisive role in body posture and locomotion by controlling skeletal muscle contraction via their motor axon termini. During embryonic development motor ... -
Identification and characterization of plant lipid droplet-associated proteins
(2024-02-23)The molecular study of plant lipid droplets, first described over a century ago, has garnered attention since the identification of oleosins in the 1980s’. In recent years, considerable progress has been achieved in ... -
Identification and functional characterization of PTK7 ligands in Xenopus laevis
(2011-10-26)Wnt signaling pathways are evolutionary conserved and regulate numerous processes in both developing and adult organisms. The canonical Wnt signaling pathway regulates cell proliferation ... -
Identification of a novel subnetwork involved in eye size variation between Drosophila melanogaster and D. mauritiana
(2022-04-07)The Mendelian genetics concept relies on simple genotype-phenotype relationships with few genes having major effects on the phenotype. However, many traits evolve by a combination of variation in many genomic loci with ... -
Identification of a septin filament required for CNS myelin integrity
(2014-04-14)Axonal integrity and longevity require functionally intact myelin, as demonstrated by the deletion of myelin-specific genes in mice. To identify molecules that contribute to the structural organization of CNS myelin, its ... -
Identification of a unique oligodendrocyte subpopulation in mouse brain
(2018-10-10)Oligodendrocytes in the central nervous system (CNS) ensheath axons with myelin and are originated from migratory and proliferative progenitor cells, so-called oligodendrocytes progenitor cells (OPCs). While immunoreactivity ... -
Identification of essential and virulence genes in Mycoplasma pneumoniae
(2019-04-16)The bacterial group of Firmicutes includes many pathogenic bacteria, as Mycoplasma pneumoniae. The Gram-positive, but cel wall-less bacterium is characterized by a minimal genome with only 694 genes. Elucidating the function ... -
Identification of factors involved in cell wall homeostasis and tolerance towards quaternary ammonium compounds in Listeria monocytogenes by genomic adaptation
(2023-06-20)Listeria monocytogenes is one of the most successful food-borne pathogens worldwide. Despite available treatment with cell wall targeting antibiotics an infection with concomitant development of listeriosis results in death ... -
Identification of host factors for the replication of the Kaposi’s sarcoma- associated herpesvirus (KSHV) and the related rhesus monkey rhadinovirus (RRV)
(2024-07-23)Kaposi’s sarcoma-associated herpesvirus (KSHV) is a human tumor virus. It is associated with Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castleman’s disease. KSHV is known to interact with several different ... -
Identification of novel components involved in selective and unselective autophagic pathways
(2012-04-11)Autophagy is a ubiquitous protein degradation pathway in eukaryotic cells. As response upon nutrient starvation, cytosolic material and also whole organelles are engulfed by a double membrane-layered vesicle, the ... -
Identification of novel rate-limiting components in Arabidopsis cell entry control against non-adapted fungal pathogens
(2024-09-27)Cell entry into host cells represents a crucial step during pathogenesis of fungal phytopathogens. However, plants have evolved an effective cell entry control mechanism to block a majority of intruders at the front line. ... -
Identification of nuclear export signals and structural analysis of transport complexes.
(2013-01-09)The nucleus is a vital sub cellular compartment and it stores the genome. Transport across the nuclear envelope occurs through Nuclear Pore Complexes (NPC) and cargo traffic across the NPCs is a highly specific and ... -
Identification of peptide-RNA heteroconjugates by mass spectrometry
(2020-10-12)Proteins and nucleic acids are two of the major constituents of life and their interplay is at the center of most biological processes. A deep understanding of the interaction between these biomolecules is crucial for ... -
Identification of the molecular changes underlying head morphology variation in closely related Drosophila species
(2016-09-09)The great diversity of adult morphologies that we can observe in nature is the product of millions of years of evolution of the underlying developmental programs. The genes that code for the transcription factors and ... -
Identification of therapeutic targets in the Burkitt’s lymphoma specific B cell antigen receptor signaling network
(2018-11-12)Burkitt’s lymphoma (BL) is an aggressive B cell neoplasm that is characterized by a chromosomal translocation, which brings the proto-oncogene c-MYC under the control of Immunoglobulin (Ig) enhancer elements leading to ...