Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Title
Now showing items 504-523 of 1169
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Keratin Networks in Live Cells
(2014-09-26)Intermediate filaments are a major component of the eukaryotic cytoskeleton along with microtubules and microfilaments and play a key role in cell mechanics. One representative of this class of proteins, which exemplifies ... -
Kinetic Analysis of Mammalian Translation Initiation
(2021-01-22)During translation initiation in mammalian cells, 80S ribosomes are assembled at the translation start site on mRNA via a cap-dependent scanning mechanism. The formation of the 80S initiation complex (IC) is essential for ... -
Kinetic analysis of neuronal SNARE protein interactions
(2022-08-08)When an action potential arrives at the axon terminal, it causes a local and transient increase in the Ca2+ concentration that starts a cascade of molecular interactions eventually leading to the fusion of synaptic vesicles ... -
Kinetic Dissection of Translation Initiation in Prokaryotes.
(2014-01-08)Ribosomes are nucleoprotein complexes which synthesize proteins in the cells. The process of translation can be subdivided into several phases: translation initiation, elongation, termination and ribosome recycling. The ... -
Kinetic models of sequential initiation events upon polysome formation
(2017-09-08)Polysomes are active protein-synthesizing units consisting of multiple ribosomes assembled along one mRNA. The frequency of ribosome loading on the mRNA defines the number of ribosomes per polysome, which is an important ... -
Kinetics of subunit rotation of the ribosome during tRNA-mRNA translocation
(2017-07-25)Ribosome dynamics play an essential role in orchestrating all stages of protein synthesis. Recent biochemical, structural and computational studies have shown large-scale conformational changes of the ribosome, its tRNA ... -
Kristallographische Untersuchungen zur Schweren Kette von Dynein und dem Capping-Protein Cap32/34
(2012-03-16)Intracellular movements are an essential prerequisite for material transport, cell division and food ingestion. They can be mediated through two different ways. Firstly, through motor ... -
Lab-on-chip design to characterize pore-spanning lipid bilayers
(2013-11-26)A powerful approach to study membrane proteins is the reconstitution in model membranes. Methods for arti cial bilayer formation are e.g. membranes on a solid support, or the classical BLM. In this project, the focus was ... -
Leaf Venation Networks
(2016-02-23)Understanding the leaf venation network is a multifaceted endeavor that requires tools from several fields of study. This thesis addresses a broad range of questions, all guided by a central theme: “How does the geometry ... -
Learning-dependent plasticity of the Drosophila mushroom body: An optophysiological approach
(2024-07-29)Functional changes in the neuronal network of our brain enable experience-dependent adaptations to the environment through our behavior, referred to as learning and memory. One fundamental topic has occupied the neurosciences ... -
Linking senses: the genetics of Drosophila larval chordotonal organs
(2018-08-06)Sensory systems have evolved in all organisms to detect changes in the environment or their internal state. Even though they are essential for fitness and survival, their phylogenisis is still unclear. The protosensory ... -
Lipid dependent interactions of biomimetic membrane models with the ENTH domain of epsin
(2020-02-05)Membrane remodeling processes during endocytosis are highly regulated by the protein-protein and protein-membrane interactions. In clathrin-mediated endocyto-sis (CME) binding of the protein epsin to its receptor lipid ... -
Lipid organisation and dynamics in the myelin membrane sheets
(2014-07-25)Myelin is a unique lipid-enriched membrane, produced by oligodendrocytes in the central nervous system, that is enwrapped around axons in the multilayered fashion to ensure a swift saltatory conduction of the neuronal ... -
Lipids in plant development and stress responses
(2023-08-22)In plant cells, lipids are important components of cellular membranes. There, they act as structure-forming and/or signal-transmitting elements. As signals, lipids are landmarks and thereby important regulators, for example ... -
Live imaging of autoimmune responses in distinct milieus of the central nervous system
(2013-08-28)Multiple sclerosis (MS) is the most common inflammatory disease of the central nervous system (CNS). Even though it is considered to be a classical demyelinating disease, an increasing body of evidence also demonstrates ... -
Localisation and function of Slam in the early Drosophila embryo
(2014-11-06)Embryogenesis of many insects starts with a syncytial stage characterised by 13 rapid nuclear divisions. During the following interphase, the plasma membrane of the embryo invaginates between each nucleus to give rise to ... -
Long-Term Temporal Dynamics of Synaptic Vesicles
(2017-09-11)Neurotransmission requires the release of neurotransmitters from synaptic vesicles. This occurs via fusion of the vesicle to the pre-synaptic membrane upon stimulation. However, not all synaptic vesicles are equally ... -
Lysosomal and mitochondrial crosstalk: the role of lysosomal signaling on mitochondrial biogenesis and function
(2018-11-15)Defects in metabolism result in various diseases, with neurodegeneration being one of the most prevalent consequences. Mitochondria and lysosomes are long known to be fundamental for cellular metabolism. In addition to ... -
Machine learning classification of patients with major depressive disorder and healthy controls using magnetic resonance imaging data
(2023-04-19)Major depressive disorder (MDD) is a prevalent and complex psychiatric disorder affecting more than 300 million people worldwide. It is characterized by a highly heterogeneous spectrum of symptoms, including low mood and ... -
Machine Learning-based Approaches to Integrate Heterogeneous Data for Biological Knowledge Transfer
(2024-06-13)Recent developments in high-throughput data generation methodologies, such as next-generation sequencing or MALDI-TOF mass spectrometry, are creating a strong necessity for data science to transform the field of biomedical ...